Induction of macrophage-derived chemokine/CCL22 expression in experimental autoimmune encephalomyelitis and cultured microglia: Implications for disease regulation

Sandra Columba-Cabezas, Barbara Serafini, Elena Ambrosini, Massimo Sanchez, Giuseppe Penna, Luciano Adorini, Francesca Aloisi

Research output: Contribution to journalArticle

Abstract

Macrophage-derived chemokine (MDC/CCL22) and its receptor CCR4 have been implicated in chronic inflammatory processes and in the homing of monocytes, Th2 cells and regulatory T-cell subsets. Here, we demonstrate that MDC and CCR4 mRNAs are expressed in the central nervous system (CNS) of mice developing relapsing-remitting and chronic-relapsing forms of experimental autoimmune encephalomyelitis (EAE). By immunohistochemistry, we show that MDC is produced by CNS-infiltrating leukocytes and intraparenchymal microglia, whereas CCR4 is expressed on some invading leukocytes. Upon in vitro activation, mouse microglia express MDC transcripts and secrete bioactive MDC that induces chemotaxis of Th2, but not Th1 cells. We suggest that MDC produced by microglia could regulate Th1-mediated CNS inflammation by facilitating the homing of Th2 and, possibly, regulatory T cells into the lesion site.

Original languageEnglish
Pages (from-to)10-21
Number of pages12
JournalJournal of Neuroimmunology
Volume130
Issue number1-2
DOIs
Publication statusPublished - Sep 2002

Keywords

  • Brain
  • Chemokines
  • EAE
  • Glia
  • Th1/Th2

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

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