About 30% of the ovulation induction cycles in GIFT and FIVET programmes are cancelled due to an inadequate response of patients to gonadotropins and/or clomiphene citrate. GnRH agonist-gonadotropins and/or 'pure' FSH combination has been successful in inducing ovulation in patients with a previous history of cycle cancellation and/or alterations in the menstrual cycles. In order to reduce the number of cycle cancellations and obtain more homogeneous oocytes, GnRH agonist-gonadotropins and/or 'pure' FSH combination in all candidates for GIFT and FIVET has been recently hypothesised. The authors report results obtained from GnRH agonist-'pure' FSH combination in 30 normally menstruating patients of the GIFT programme: in 93% of cases the harvested oocytes were preovulatory, in 27.6% of cycles and in 28.6% of the GIFTs respectively an ongoing pregnancy was obtained. While the results obtained must be considered preliminary, they nevertheless suggest that the use of a combination of GnRH-agonist 'pure' FSH in all patients in the GIFT programme may be of a real clinical validity.
|Number of pages||7|
|Journal||Acta Europaea Fertilitatis|
|Publication status||Published - 1988|
ASJC Scopus subject areas
- Obstetrics and Gynaecology