Induction of ovulation for gamete intrafallopian transfer (GIFT) using a gonadotropin-releasing hormone agonist and 'pure' FSH: Results obtained in 30 normally menstruating women

G. B. La Sala, M. Cantarelli, G. Parolari, L. Dessanti, D. Dall'Asta, M. G. Torelli, V. Salvatore, C. Dotti, S. Cavalieri, L. Brai, G. Parmiggiani

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Abstract

About 30% of the ovulation induction cycles in GIFT and FIVET programmes are cancelled due to an inadequate response of patients to gonadotropins and/or clomiphene citrate. GnRH agonist-gonadotropins and/or 'pure' FSH combination has been successful in inducing ovulation in patients with a previous history of cycle cancellation and/or alterations in the menstrual cycles. In order to reduce the number of cycle cancellations and obtain more homogeneous oocytes, GnRH agonist-gonadotropins and/or 'pure' FSH combination in all candidates for GIFT and FIVET has been recently hypothesised. The authors report results obtained from GnRH agonist-'pure' FSH combination in 30 normally menstruating patients of the GIFT programme: in 93% of cases the harvested oocytes were preovulatory, in 27.6% of cycles and in 28.6% of the GIFTs respectively an ongoing pregnancy was obtained. While the results obtained must be considered preliminary, they nevertheless suggest that the use of a combination of GnRH-agonist 'pure' FSH in all patients in the GIFT programme may be of a real clinical validity.

Original languageEnglish
Pages (from-to)159-165
Number of pages7
JournalActa Europaea Fertilitatis
Volume19
Issue number3
Publication statusPublished - 1988

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ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

La Sala, G. B., Cantarelli, M., Parolari, G., Dessanti, L., Dall'Asta, D., Torelli, M. G., Salvatore, V., Dotti, C., Cavalieri, S., Brai, L., & Parmiggiani, G. (1988). Induction of ovulation for gamete intrafallopian transfer (GIFT) using a gonadotropin-releasing hormone agonist and 'pure' FSH: Results obtained in 30 normally menstruating women. Acta Europaea Fertilitatis, 19(3), 159-165.