Induction of peripheral T cell tolerance by antigen-presenting B cells. I. Relevance of antigen presentation persistence

Giorgio Raimondi, Ivan Zanoni, Stefania Citterio, Paola Ricciardi-Castagnoli, Francesca Granucci

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Various mechanisms of peripheral T cell tolerization have evolved to avoid responses mediated by autoreactive T cells that have not been eliminated in the thymus. In this study, we investigated the peripheral conditions of Ag presentation required to induce T cell tolerance when the predominant APCs are B cells. We show that transient Ag presentation, in absence of inflammation and in a self-context, induces CD4+ T cell activation and memory formation. In contrast, chronic Ag presentation leads to CD4+ T cell tolerance. The importance of long-lasting Ag presentation in inducing tolerance was also confirmed in the herpes stromal keratitis autoimmune disease model. Keratogenic T cells could be activated or tolerized depending on the APC short or long persistence. Thus, when APCs are B cells, the persistence of the Ag presentation itself is one of the main conditions to have peripheral T cell tolerance.

Original languageEnglish
Pages (from-to)4012-4020
Number of pages9
JournalJournal of Immunology
Volume176
Issue number7
Publication statusPublished - Apr 1 2006

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Antigen Presentation
Antigen-Presenting Cells
B-Lymphocytes
T-Lymphocytes
Keratitis
I-antigen
Thymus Gland
Autoimmune Diseases
Inflammation

ASJC Scopus subject areas

  • Immunology

Cite this

Raimondi, G., Zanoni, I., Citterio, S., Ricciardi-Castagnoli, P., & Granucci, F. (2006). Induction of peripheral T cell tolerance by antigen-presenting B cells. I. Relevance of antigen presentation persistence. Journal of Immunology, 176(7), 4012-4020.

Induction of peripheral T cell tolerance by antigen-presenting B cells. I. Relevance of antigen presentation persistence. / Raimondi, Giorgio; Zanoni, Ivan; Citterio, Stefania; Ricciardi-Castagnoli, Paola; Granucci, Francesca.

In: Journal of Immunology, Vol. 176, No. 7, 01.04.2006, p. 4012-4020.

Research output: Contribution to journalArticle

Raimondi, G, Zanoni, I, Citterio, S, Ricciardi-Castagnoli, P & Granucci, F 2006, 'Induction of peripheral T cell tolerance by antigen-presenting B cells. I. Relevance of antigen presentation persistence', Journal of Immunology, vol. 176, no. 7, pp. 4012-4020.
Raimondi G, Zanoni I, Citterio S, Ricciardi-Castagnoli P, Granucci F. Induction of peripheral T cell tolerance by antigen-presenting B cells. I. Relevance of antigen presentation persistence. Journal of Immunology. 2006 Apr 1;176(7):4012-4020.
Raimondi, Giorgio ; Zanoni, Ivan ; Citterio, Stefania ; Ricciardi-Castagnoli, Paola ; Granucci, Francesca. / Induction of peripheral T cell tolerance by antigen-presenting B cells. I. Relevance of antigen presentation persistence. In: Journal of Immunology. 2006 ; Vol. 176, No. 7. pp. 4012-4020.
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