Induction of protooncogene fos by extracellular signals in primary glial cell cultures

D. F. Condorelli, L. Kaczmarek, F. Nicoletti, A. Arcidiacono, P. Dell'Albani, F. Ingrao, G. Magri, L. Malaguarnera, R. Avola, A. Messina, A. M. Giuffrida Stella

Research output: Contribution to journalArticlepeer-review

Abstract

In the present study various extracellular factors, acting through different second messenger systems, were examined for their capacity to increase the level of c-fos mRNA in primary glial cell cultures. In particular EGF, 12-O-tetradecanoylphorbol 13-acetate, the beta-adrenergic agonist isoproterenol, and the glutamate agonists, ibotenic and quisqualic acid, were studied. All the extracellular stimuli tested induced a rapid and transient increase in c-fos mRNA level in glial cell cultures regardless of the signal transduction pathway and the final effect on cell proliferation.

Original languageEnglish
Pages (from-to)234-239
Number of pages6
JournalJournal of Neuroscience Research
Volume23
Issue number2
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Induction of protooncogene fos by extracellular signals in primary glial cell cultures'. Together they form a unique fingerprint.

Cite this