TY - JOUR
T1 - Induction of protooncogene fos by extracellular signals in primary glial cell cultures
AU - Condorelli, D. F.
AU - Kaczmarek, L.
AU - Nicoletti, F.
AU - Arcidiacono, A.
AU - Dell'Albani, P.
AU - Ingrao, F.
AU - Magri, G.
AU - Malaguarnera, L.
AU - Avola, R.
AU - Messina, A.
AU - Giuffrida Stella, A. M.
PY - 1989
Y1 - 1989
N2 - In the present study various extracellular factors, acting through different second messenger systems, were examined for their capacity to increase the level of c-fos mRNA in primary glial cell cultures. In particular EGF, 12-O-tetradecanoylphorbol 13-acetate, the beta-adrenergic agonist isoproterenol, and the glutamate agonists, ibotenic and quisqualic acid, were studied. All the extracellular stimuli tested induced a rapid and transient increase in c-fos mRNA level in glial cell cultures regardless of the signal transduction pathway and the final effect on cell proliferation.
AB - In the present study various extracellular factors, acting through different second messenger systems, were examined for their capacity to increase the level of c-fos mRNA in primary glial cell cultures. In particular EGF, 12-O-tetradecanoylphorbol 13-acetate, the beta-adrenergic agonist isoproterenol, and the glutamate agonists, ibotenic and quisqualic acid, were studied. All the extracellular stimuli tested induced a rapid and transient increase in c-fos mRNA level in glial cell cultures regardless of the signal transduction pathway and the final effect on cell proliferation.
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M3 - Article
C2 - 2547086
AN - SCOPUS:0024361568
VL - 23
SP - 234
EP - 239
JO - Journal of Neuroscience Research
JF - Journal of Neuroscience Research
SN - 0360-4012
IS - 2
ER -