Induction of regulatory T cells by dendritic cells through indoleamine 2,3-dioxygenase: A potent mechanism of acquired peripheral tolerance

S. Trabanelli, D. Ocadlikova, C. Evangelisti, S. Parisi, A. Curti

Research output: Contribution to journalArticle

Abstract

Indoleamine 2,3-dioxygenase (IDO) is an intracellular heme-containing enzyme that catalyzes the initial rate-limiting step in tryptophan degradation along the kynurenine pathway. Recent works have demonstrated a crucial role for IDO in the induction of immune tolerance during infections, pregnancy, transplantation, autoimmunity, and neoplasias. IDO is widely expressed in human tissues and cell subsets, including dendritic cells, where it modulates their function by increasing tolerogenic capacities. The aim of the present paper is to highlight the most recent data about IDO expression in dendritic cells and its role as a potent inducer of T regulatory cells.

Original languageEnglish
Pages (from-to)2234-2239
Number of pages6
JournalCurrent Medicinal Chemistry
Volume18
Issue number15
Publication statusPublished - May 2011

Keywords

  • Dendritic cells
  • Indoleamine 2,3-dioxygenase
  • T regulatory cells

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Fingerprint Dive into the research topics of 'Induction of regulatory T cells by dendritic cells through indoleamine 2,3-dioxygenase: A potent mechanism of acquired peripheral tolerance'. Together they form a unique fingerprint.

  • Cite this