Flunarizine has been suggested as add-on treatment in pharmacoresistant epileptic patients. Because of discordant experiences we studied its effectiveness in patients with epilepsy and mental retardation, using a double-blind cross-over protocol. After 3 months of observation, 26 young mentally retarded epileptic patients were randomly assigned to 10 mg/die Flunarizine or placebo add-on therapy. Each treatment was continued for 3 months, separated by a 3 month period of wash out. Number of seizures and behavioural observations were recorded. In 15 out of 26 subjects attention test, EEG interictal spinking rates, BAEPs and AEDs plasma level were also evaluated during basal conditions and at the end of each treatment. No significant findings were obtained, suggesting that antiepileptic properties of Flunarizine need further validation, in view also of the possible side-effects during long-term treatment.
|Title of host publication||Bollettino - Lega Italiana contro l'Epilessia|
|Number of pages||2|
|Publication status||Published - 1988|
ASJC Scopus subject areas
- Clinical Neurology