Infant neurodevelopmental outcome in pregnancies complicated by gestational hypertension and intrauterine growth retardation

Arsenio Spinillo, Secondo Guaschino, Mauro Stronati, Alessandra Ometto, Elisa Fazzi, G. Giovanni

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The neonatal outcome of 78 consecutive singleton pregnancies complicated by intrauterine growth retardation (IUGR) and gestational hypertension were compared with the outcome of 78 adequately matched pregnancies complicated by idiopathic IUGR. The rate of low (<5) 1-minute Apgar scores was higher in infants born to hypertensive mothers (12.8% vs 2.6% p =.035). No differences in the prevalence of other perinatal factors such as acidosis, respiratory distress syndrome, hypoglycemia, pneu-mothorax, bronchopulmonary dysplasia, intracranial hemorrhage, requirement for assisted ventilation or survival were found between cases and controls. After two years’ follow-up, the rate of major neurological neonatal handicaps, was 2.8% in the cases and 1.4% in the controls (p = 0.56). Mild neuro-developmental abnormalities were more frequent in infants born to hypertensive mothers (14.3% vs 2.9% p =.025). After adjustment by multiple logistic regression, to eliminate the effect of confounding factors, the probability of normal neurodevelopmental outcome was reduced by 82% in infants born to hypertensive mothers as compared to controls (Odds Ratio = 0.18; 95% confidence interval 0.05 to 0.82 p =.028). These findings suggest that pregnancies complicated by IUGR and gestational hypertension are associated with a high prevalence of subsequent neurodevelopmental problems among infants.

Original languageEnglish
Pages (from-to)195-203
Number of pages9
JournalJournal of Perinatal Medicine
Volume21
Issue number3
DOIs
Publication statusPublished - 1993

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Pregnancy Induced Hypertension
Fetal Growth Retardation
Pregnancy Outcome
Mothers
Pregnancy
Respiratory Acidosis
Social Adjustment
Bronchopulmonary Dysplasia
Apgar Score
Intracranial Hemorrhages
Hypoglycemia
Ventilation
Logistic Models
Odds Ratio
Confidence Intervals

Keywords

  • eurologische Entwicklung beim Kind
  • Infant neurodevelopmental outcome
  • Intrakranielle Blutungen beim Neugeborenen
  • intrauterine Wachstumsretardierung
  • intrauterine-growth retardation
  • neonatal intracranial haemorrhage
  • neonatal mortality
  • neonatale Mortalität

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Pediatrics, Perinatology, and Child Health

Cite this

Infant neurodevelopmental outcome in pregnancies complicated by gestational hypertension and intrauterine growth retardation. / Spinillo, Arsenio; Guaschino, Secondo; Stronati, Mauro; Ometto, Alessandra; Fazzi, Elisa; Giovanni, G.

In: Journal of Perinatal Medicine, Vol. 21, No. 3, 1993, p. 195-203.

Research output: Contribution to journalArticle

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