Infants born to mothers under phenobarbital treatment: Correlation between serum levels and clinical features of neonates

Antonio A. Zuppa, Chiara Carducci, Antonio Scorrano, Eleonora Antichi, Piero Catenazzi, Andrea Piras, Giacomo Pozzoli, Valentina Cardiello, Annamaria D'Antuono, Costantino Romagnoli

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Phenobarbital crosses the placenta quickly, and the balance between maternal and fetal blood is achieved in a few minutes. Data on the clinical outcomes of infants born to mothers under phenobarbital treatment during pregnancy show that they are at risk of adverse events, such as sedation and abstinence syndrome. The aim of this study was to analyse the correlation between serum levels of phenobarbital and clinical features of neonates. Study design: Twenty-three infants born between 2001 and 2008 were studied. Maternal, neonatal and pharmacological variables were considered. Results: Eleven infants displayed symptoms related to phenobarbital. Withdrawal syndrome was seen in seven infants and sedation syndrome was seen in four infants. One infant had severe cardiorespiratory depression at birth. None of the infants had severe neonatal abstinence syndrome. No statistically significant differences were found between symptomatic and asymptomatic infants. At birth, the mean serum level of phenobarbital of the 23 infants was 15.4 [standard deviation (SD) 6.2] μg/ml. A peak (16.1 μg/ml, SD 5.5) was seen on Day 3, followed by a gradual decrease to non-therapeutic levels (

Original languageEnglish
Pages (from-to)53-56
Number of pages4
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Volume159
Issue number1
DOIs
Publication statusPublished - Nov 2011

Keywords

  • Abstinence syndrome
  • Epileptic mother
  • Newborn
  • Phenobarbital levels

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

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