Infection of dendritic cells by murine cytomegalovirus induces functional paralysis

Daniel M. Andrews, Christopher E. Andoniou, Francesca Granucci, Paola Ricciardi-Castagnoli, Mariapia A. Degli-Esposti

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Abstract

Cytomegalovirus (CMV), measles and HIV are the main human pathogens known to induce immunosuppression. Unlike measles and HIV, and despite the availability of a well studied animal model, little is known about the mechanisms that control CMV-induced immunosuppression. We hypothesized that dendritic cells (DCs), which are crucial in generating and maintaining immune responses, represent a target for CMV and that the transient, but profound, immunosuppression that accompanies CMV infection results from viral interference with DC functions. Here we show that DCs were permissive to murine CMV infection. In addition, DC infection prevented delivery of the signals required for T cell activation. Thus, CMV-mediated impairment of DC function may be crucial for virally induced immunosuppression and interleukin 2 is implicated as a key factor.

Original languageEnglish
Pages (from-to)1077-1084
Number of pages8
JournalNature Immunology
Volume2
Issue number11
DOIs
Publication statusPublished - 2001

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ASJC Scopus subject areas

  • Immunology

Cite this

Andrews, D. M., Andoniou, C. E., Granucci, F., Ricciardi-Castagnoli, P., & Degli-Esposti, M. A. (2001). Infection of dendritic cells by murine cytomegalovirus induces functional paralysis. Nature Immunology, 2(11), 1077-1084. https://doi.org/10.1038/ni724