Abstract
Cytomegalovirus (CMV), measles and HIV are the main human pathogens known to induce immunosuppression. Unlike measles and HIV, and despite the availability of a well studied animal model, little is known about the mechanisms that control CMV-induced immunosuppression. We hypothesized that dendritic cells (DCs), which are crucial in generating and maintaining immune responses, represent a target for CMV and that the transient, but profound, immunosuppression that accompanies CMV infection results from viral interference with DC functions. Here we show that DCs were permissive to murine CMV infection. In addition, DC infection prevented delivery of the signals required for T cell activation. Thus, CMV-mediated impairment of DC function may be crucial for virally induced immunosuppression and interleukin 2 is implicated as a key factor.
| Original language | English |
|---|---|
| Pages (from-to) | 1077-1084 |
| Number of pages | 8 |
| Journal | Nature Immunology |
| Volume | 2 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2001 |
Fingerprint
ASJC Scopus subject areas
- Immunology
Cite this
Infection of dendritic cells by murine cytomegalovirus induces functional paralysis. / Andrews, Daniel M.; Andoniou, Christopher E.; Granucci, Francesca; Ricciardi-Castagnoli, Paola; Degli-Esposti, Mariapia A.
In: Nature Immunology, Vol. 2, No. 11, 2001, p. 1077-1084.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Infection of dendritic cells by murine cytomegalovirus induces functional paralysis
AU - Andrews, Daniel M.
AU - Andoniou, Christopher E.
AU - Granucci, Francesca
AU - Ricciardi-Castagnoli, Paola
AU - Degli-Esposti, Mariapia A.
PY - 2001
Y1 - 2001
N2 - Cytomegalovirus (CMV), measles and HIV are the main human pathogens known to induce immunosuppression. Unlike measles and HIV, and despite the availability of a well studied animal model, little is known about the mechanisms that control CMV-induced immunosuppression. We hypothesized that dendritic cells (DCs), which are crucial in generating and maintaining immune responses, represent a target for CMV and that the transient, but profound, immunosuppression that accompanies CMV infection results from viral interference with DC functions. Here we show that DCs were permissive to murine CMV infection. In addition, DC infection prevented delivery of the signals required for T cell activation. Thus, CMV-mediated impairment of DC function may be crucial for virally induced immunosuppression and interleukin 2 is implicated as a key factor.
AB - Cytomegalovirus (CMV), measles and HIV are the main human pathogens known to induce immunosuppression. Unlike measles and HIV, and despite the availability of a well studied animal model, little is known about the mechanisms that control CMV-induced immunosuppression. We hypothesized that dendritic cells (DCs), which are crucial in generating and maintaining immune responses, represent a target for CMV and that the transient, but profound, immunosuppression that accompanies CMV infection results from viral interference with DC functions. Here we show that DCs were permissive to murine CMV infection. In addition, DC infection prevented delivery of the signals required for T cell activation. Thus, CMV-mediated impairment of DC function may be crucial for virally induced immunosuppression and interleukin 2 is implicated as a key factor.
UR - http://www.scopus.com/inward/record.url?scp=0035164788&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035164788&partnerID=8YFLogxK
U2 - 10.1038/ni724
DO - 10.1038/ni724
M3 - Article
VL - 2
SP - 1077
EP - 1084
JO - Nature Immunology
JF - Nature Immunology
SN - 1529-2908
IS - 11
ER -