Infection of dendritic cells by murine cytomegalovirus induces functional paralysis

Daniel M. Andrews, Christopher E. Andoniou, Francesca Granucci, Paola Ricciardi-Castagnoli, Mariapia A. Degli-Esposti

Research output: Contribution to journalArticle

217 Citations (Scopus)

Abstract

Cytomegalovirus (CMV), measles and HIV are the main human pathogens known to induce immunosuppression. Unlike measles and HIV, and despite the availability of a well studied animal model, little is known about the mechanisms that control CMV-induced immunosuppression. We hypothesized that dendritic cells (DCs), which are crucial in generating and maintaining immune responses, represent a target for CMV and that the transient, but profound, immunosuppression that accompanies CMV infection results from viral interference with DC functions. Here we show that DCs were permissive to murine CMV infection. In addition, DC infection prevented delivery of the signals required for T cell activation. Thus, CMV-mediated impairment of DC function may be crucial for virally induced immunosuppression and interleukin 2 is implicated as a key factor.

Original languageEnglish
Pages (from-to)1077-1084
Number of pages8
JournalNature Immunology
Volume2
Issue number11
DOIs
Publication statusPublished - 2001

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Muromegalovirus
Paralysis
Dendritic Cells
Cytomegalovirus
Immunosuppression
Infection
Cytomegalovirus Infections
Measles
Viral Interference
HIV
Interleukin-2
Animal Models
T-Lymphocytes

ASJC Scopus subject areas

  • Immunology

Cite this

Andrews, D. M., Andoniou, C. E., Granucci, F., Ricciardi-Castagnoli, P., & Degli-Esposti, M. A. (2001). Infection of dendritic cells by murine cytomegalovirus induces functional paralysis. Nature Immunology, 2(11), 1077-1084. https://doi.org/10.1038/ni724

Infection of dendritic cells by murine cytomegalovirus induces functional paralysis. / Andrews, Daniel M.; Andoniou, Christopher E.; Granucci, Francesca; Ricciardi-Castagnoli, Paola; Degli-Esposti, Mariapia A.

In: Nature Immunology, Vol. 2, No. 11, 2001, p. 1077-1084.

Research output: Contribution to journalArticle

Andrews, DM, Andoniou, CE, Granucci, F, Ricciardi-Castagnoli, P & Degli-Esposti, MA 2001, 'Infection of dendritic cells by murine cytomegalovirus induces functional paralysis', Nature Immunology, vol. 2, no. 11, pp. 1077-1084. https://doi.org/10.1038/ni724
Andrews DM, Andoniou CE, Granucci F, Ricciardi-Castagnoli P, Degli-Esposti MA. Infection of dendritic cells by murine cytomegalovirus induces functional paralysis. Nature Immunology. 2001;2(11):1077-1084. https://doi.org/10.1038/ni724
Andrews, Daniel M. ; Andoniou, Christopher E. ; Granucci, Francesca ; Ricciardi-Castagnoli, Paola ; Degli-Esposti, Mariapia A. / Infection of dendritic cells by murine cytomegalovirus induces functional paralysis. In: Nature Immunology. 2001 ; Vol. 2, No. 11. pp. 1077-1084.
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