Background: To estimate the prevalence of infection with human herpes virus type 8 (HHV8) and the incidence of Kaposi's sarcoma among HHV8-infected individuals, we conducted a population-based, cross-sectional study in Latina. This area of central ItaLy was formerly endemic for malaria and it is now covered by a population-based cancer registry. Materials and Methods: Residual sera samples from 200 persons (100 men and 100 women) aged 50 years or older, randomly selected from a larger population-based survey on cardiovascular diseases, were tested for antibodies against HHV8. HHV8 seroprevalence and yearly incidence rates of Kaposi's sarcoma (KS) among HHV8-positive persons were computed. Results: HHV8 infection was not significantly higher in men (9.0%, 95% CI: 3.4-14.6) than in women (6.0%, 95% CI: 1.3-10.7). The estimated yearly incidence rate of KS among HHV8-positive persons was twice as high in men (1:2,200) as in women (1:4,110). Conclusion: These results were comparable to those derived from geographic areas at Low risk for KS where malaria was not endemic (e.g. Malta). The seemingly higher incidence of KS among HHV8-positive men suggests that different cofactors for the two sexes are LikeLy to play a role in KS etiology.
ASJC Scopus subject areas
- Microbiology (medical)