Infection with human herpesvirus type 8 and Kaposi's sarcoma in a central Italian area formerly endemic for malaria

D. Serraino, R. M. Corona, M. Giuliani, F. Farchi, L. Sarmati, I. Uccella, M. Andreoni, G. Rezza

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Abstract

Background: To estimate the prevalence of infection with human herpes virus type 8 (HHV8) and the incidence of Kaposi's sarcoma among HHV8-infected individuals, we conducted a population-based, cross-sectional study in Latina. This area of central ItaLy was formerly endemic for malaria and it is now covered by a population-based cancer registry. Materials and Methods: Residual sera samples from 200 persons (100 men and 100 women) aged 50 years or older, randomly selected from a larger population-based survey on cardiovascular diseases, were tested for antibodies against HHV8. HHV8 seroprevalence and yearly incidence rates of Kaposi's sarcoma (KS) among HHV8-positive persons were computed. Results: HHV8 infection was not significantly higher in men (9.0%, 95% CI: 3.4-14.6) than in women (6.0%, 95% CI: 1.3-10.7). The estimated yearly incidence rate of KS among HHV8-positive persons was twice as high in men (1:2,200) as in women (1:4,110). Conclusion: These results were comparable to those derived from geographic areas at Low risk for KS where malaria was not endemic (e.g. Malta). The seemingly higher incidence of KS among HHV8-positive men suggests that different cofactors for the two sexes are LikeLy to play a role in KS etiology.

Original languageEnglish
Pages (from-to)47-50
Number of pages4
JournalInfection
Volume31
Issue number1
DOIs
Publication statusPublished - Jan 2003

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ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology

Cite this

Serraino, D., Corona, R. M., Giuliani, M., Farchi, F., Sarmati, L., Uccella, I., Andreoni, M., & Rezza, G. (2003). Infection with human herpesvirus type 8 and Kaposi's sarcoma in a central Italian area formerly endemic for malaria. Infection, 31(1), 47-50. https://doi.org/10.1007/s15010-002-3107-9