Infections after lung transplantation

Mario Nosotti, Paolo Tarsia, Letizia Corinna Morlacchi

Research output: Contribution to journalReview article

Abstract

The good clinical result of lung transplantation is constantly undermined by the high incidence of infection, which negatively impacts on function and survival. Moreover, infections may also have immunological interactions that play a role in the acute rejection and in the development of chronic lung allograft dysfunction. There is a temporal sequence in the types of infection that affects lung allograft: in the first postoperative month bacteria are the most frequent cause of infection; following this phase, cytomegalovirus and Pneumocystis carinii are common. Fungal infections are particularly feared due to their association with bronchial complication and high mortality. Scrupulous postoperative surveillance is mandatory for the successful management of lung transplantation patients with respect to early detection and treatment of infections. This paper is aimed to address clinicians in the management of the major infectious complications that affect the lung transplant population.

Original languageEnglish
Pages (from-to)3849-3868
Number of pages20
JournalJournal of Thoracic Disease
Volume10
Issue number6
DOIs
Publication statusPublished - Jun 1 2018

Keywords

  • Bacterial infections
  • Lung transplantation
  • Mycoses
  • Postoperative complications
  • Virus diseases

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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