Infections as triggers and complications of systemic lupus erythematosus

A. Doria, M. Canova, M. Tonon, M. Zen, E. Rampudda, N. Bassi, F. Atzeni, S. Zampieri, A. Ghirardello

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

A growing body of experimental and clinical evidence supports the pivotal role of infections in the induction or exacerbation of systemic lupus erythematosus (SLE). Infections can be responsible for aberrant immune response leading to a loss of tolerance towards native proteins. Molecular mimicry, especially between Sm or Ro autoantigens and EBV Nuclear Antigen-1 response, as well as the over-expression of type 1 INF genes are among the major contributors to SLE development. On the other hand infections are very common in SLE patients, where they are responsible for 30-50% of morbidity and mortality. Several factors, either genetic, including complement deficiencies or mannose-binding lectin deficiency or acquired such as severe disease manifestations or immunosuppressant use, predispose SLE patients to infections. All types of infections, including bacterial, viral and opportunistic infections, have been reported and the most frequently involved sites of infections are the same as those observed in the general population, including respiratory, skin, and urinary tract infections. Some preventive measures could be adopted in order to reduce the rate of infections in SLE patients: i.e. screening for Mycobacterium tuberculosis and for some chronic viral infections before immunosuppressive treatment; adequate prophylaxes or drug adjustments when indicated, and pneumococcal and influenza vaccinations in patients with stable disease.

Original languageEnglish
Pages (from-to)24-28
Number of pages5
JournalAutoimmunity Reviews
Volume8
Issue number1
DOIs
Publication statusPublished - Oct 2008

Fingerprint

Systemic Lupus Erythematosus
Infection
Virus Diseases
Immunosuppressive Agents
Epstein-Barr Virus Nuclear Antigens
Molecular Mimicry
Opportunistic Infections
Mycobacterium tuberculosis
Bacterial Infections
Urinary Tract Infections
Respiratory Tract Infections
Human Influenza
Vaccination
Morbidity
Skin
Mortality
Pharmaceutical Preparations
Population
Genes
Proteins

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Doria, A., Canova, M., Tonon, M., Zen, M., Rampudda, E., Bassi, N., ... Ghirardello, A. (2008). Infections as triggers and complications of systemic lupus erythematosus. Autoimmunity Reviews, 8(1), 24-28. https://doi.org/10.1016/j.autrev.2008.07.019

Infections as triggers and complications of systemic lupus erythematosus. / Doria, A.; Canova, M.; Tonon, M.; Zen, M.; Rampudda, E.; Bassi, N.; Atzeni, F.; Zampieri, S.; Ghirardello, A.

In: Autoimmunity Reviews, Vol. 8, No. 1, 10.2008, p. 24-28.

Research output: Contribution to journalArticle

Doria, A, Canova, M, Tonon, M, Zen, M, Rampudda, E, Bassi, N, Atzeni, F, Zampieri, S & Ghirardello, A 2008, 'Infections as triggers and complications of systemic lupus erythematosus', Autoimmunity Reviews, vol. 8, no. 1, pp. 24-28. https://doi.org/10.1016/j.autrev.2008.07.019
Doria, A. ; Canova, M. ; Tonon, M. ; Zen, M. ; Rampudda, E. ; Bassi, N. ; Atzeni, F. ; Zampieri, S. ; Ghirardello, A. / Infections as triggers and complications of systemic lupus erythematosus. In: Autoimmunity Reviews. 2008 ; Vol. 8, No. 1. pp. 24-28.
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