Infections in neuro-oncology.

P. Gaviani, A. Silvani, E. Lamperti, A. Botturi, G. Simonetti, I. Milanesi, D. Ferrari, A. Salmaggi

Research output: Contribution to journalArticle

Abstract

Infections represent a serious and frequent complication in neuro-oncology patients. Decreased immune defences, along with poor nutritional status are the main predisposition factors. The combined therapeutic strategies of chemotherapy and radiotherapy may favour bone marrow depression and further increase the risk of developing opportunistic infections in brain tumour patients. The spectrum of infections in neuro-oncology patients is large and includes opportunistic infections by bacteria, viruses, fungi and parasites. Importantly, a high index of suspicion for opportunistic infections in general should be maintained, especially in glioma patients receiving dose-dense schedules of temozolomide. After neurosurgical procedures, infections most commonly present as meningitis, subdural empyema, or cerebral abscess. Infections represent a frequent and possibly serious complication in general immunocompromised oncology population. It should be underlined that infections are not limited to immunocompromised patients, being also present at the early disease stages, especially due to therapeutic strategies (chemo and radiotherapy, surgical procedures). Therefore this issue deserves more attention in neuroncology setting.

Original languageEnglish
JournalNeurological Sciences
Volume32 Suppl 2
Publication statusPublished - Nov 2011

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Opportunistic Infections
Infection
temozolomide
Radiotherapy
Subdural Empyema
Neurosurgical Procedures
Brain Abscess
Immunocompromised Host
Nutritional Status
Meningitis
Brain Neoplasms
Glioma
Appointments and Schedules
Parasites
Fungi
Bone Marrow
Viruses
Bacteria
Drug Therapy
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gaviani, P., Silvani, A., Lamperti, E., Botturi, A., Simonetti, G., Milanesi, I., ... Salmaggi, A. (2011). Infections in neuro-oncology. Neurological Sciences, 32 Suppl 2.

Infections in neuro-oncology. / Gaviani, P.; Silvani, A.; Lamperti, E.; Botturi, A.; Simonetti, G.; Milanesi, I.; Ferrari, D.; Salmaggi, A.

In: Neurological Sciences, Vol. 32 Suppl 2, 11.2011.

Research output: Contribution to journalArticle

Gaviani, P, Silvani, A, Lamperti, E, Botturi, A, Simonetti, G, Milanesi, I, Ferrari, D & Salmaggi, A 2011, 'Infections in neuro-oncology.', Neurological Sciences, vol. 32 Suppl 2.
Gaviani, P. ; Silvani, A. ; Lamperti, E. ; Botturi, A. ; Simonetti, G. ; Milanesi, I. ; Ferrari, D. ; Salmaggi, A. / Infections in neuro-oncology. In: Neurological Sciences. 2011 ; Vol. 32 Suppl 2.
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