Le complicanze infettive dopo trapianto di rene.

Translated title of the contribution: Infectious complications after renal transplantation

P. Viale, L. Scudeller

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Infections still represent a major clinical issue in the field of renal transplantation, impacting on graft and patient survival. Post-surgical complications in the immediate post-transplantation period, and immunosuppression (related to the use of new drugs such as mycophenolate mofetil, rapamicin, sirolimus and tacrolimus, and of increasingly aggressive immunosuppressive regimens) in later phases entail an increased risk for infection. Bacteria (in particular Enterobacteriaceae, non-fermenting Gram-negative bacilli and Enterococcus spp) and Candida spp are a frequent cause of urinary tract infection in the early post-transplantation phase. Cytomegalovirus (CMV) is a frequent infectious complication (20-60% of patients) whose risk is enhanced by mycophenolate mofetil. It can cause a variety of diseases: organ or disseminated acute disease, acute graft rejection, chronic allograft nephropathy, graft glomerulopathy, renal artery stenosis, induction of secondary bacterial or mycotic disease. Monitoring CMV antigenemia (pp65) allows a strategy based on pre-emptive therapy among patients with evidence of virological activity. BK virus (BKV) is a polyomavirus associated to various clinical syndromes in severely immunocompromised patients, such as haemorrhagic cystitis, ureteral stenosis and others. The variety and severity of infectious complications in this field mandate a multidisciplinary approach involving, next to the nephrologist and the surgeon, an infectious disease consultant and a clinical microbiologist.

Original languageItalian
JournalGiornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia
Volume21 Suppl 26
Publication statusPublished - Jan 2004

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Kidney Transplantation
Mycophenolic Acid
Cytomegalovirus
Transplantation
BK Virus
Polyomavirus
Renal Artery Obstruction
Cystitis
Enterococcus
Graft Rejection
Immunocompromised Host
Tacrolimus
Acute Disease
Graft Survival
Enterobacteriaceae
Sirolimus
Immunosuppressive Agents
Consultants
Infection
Candida

ASJC Scopus subject areas

  • Nephrology

Cite this

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abstract = "Infections still represent a major clinical issue in the field of renal transplantation, impacting on graft and patient survival. Post-surgical complications in the immediate post-transplantation period, and immunosuppression (related to the use of new drugs such as mycophenolate mofetil, rapamicin, sirolimus and tacrolimus, and of increasingly aggressive immunosuppressive regimens) in later phases entail an increased risk for infection. Bacteria (in particular Enterobacteriaceae, non-fermenting Gram-negative bacilli and Enterococcus spp) and Candida spp are a frequent cause of urinary tract infection in the early post-transplantation phase. Cytomegalovirus (CMV) is a frequent infectious complication (20-60{\%} of patients) whose risk is enhanced by mycophenolate mofetil. It can cause a variety of diseases: organ or disseminated acute disease, acute graft rejection, chronic allograft nephropathy, graft glomerulopathy, renal artery stenosis, induction of secondary bacterial or mycotic disease. Monitoring CMV antigenemia (pp65) allows a strategy based on pre-emptive therapy among patients with evidence of virological activity. BK virus (BKV) is a polyomavirus associated to various clinical syndromes in severely immunocompromised patients, such as haemorrhagic cystitis, ureteral stenosis and others. The variety and severity of infectious complications in this field mandate a multidisciplinary approach involving, next to the nephrologist and the surgeon, an infectious disease consultant and a clinical microbiologist.",
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