Infectious complications in the renal transplant recipient

A. Grimaldi, A. Barletta, M. Rascente, F. Pisani, G. Iaria, D. MacCarone, E. Maira, M. D'Angelo, A. Famulari

Research output: Contribution to journalArticle

Abstract

The aim of this study was to estimate the incidence of infectious diseases in a group of patients who underwent kidney transplantation from January 1, 2004 to September 30, 2004, including 121 operations, with 119 from cadaveric and 2 from living donors. The protocol sought herpes viruses (CMV, VZV, and EBV), hepatitis viruses, human immunodeficiency virus, T. gondii, M. tubercolosis, and T. pallidum. Therapy for CMV was used both as prophylaxis in immunoglobulin (Ig)G-negative recipients from IgG-positive donors and preemptive therapy, that is, before the appearance of clinical symptoms, but after viremia reached borderline levels. For VZV infections, the treatment started after the appearance of papulo-vesicular cutaneous eruptions and antibody positivity. The treatment for pneumonia consisted of empirical therapy after radiography; for pyelonephritis, antibiotic therapy was based on the results of kidney echography, blood culture, and urine culture. Infectious complications appeared in 25 patients (20.7%), 3 of the which were polymicrobic: 12 CMV infections, 9 VZV infections, 3 pneumoniae, 4 pyelonephritis, and 1 salmonellosis. The most frequent infection was CMV, which occurred in the first 3 months after transplantation in 9 of 12 cases. This study showed that a knowledge of infection prevalence can help the physician to establish a more specific, efficacious antimicrobial therapy, despite the laboratory response not being available in a short time.

Original languageEnglish
Pages (from-to)2502-2503
Number of pages2
JournalTransplantation Proceedings
Volume37
Issue number6
DOIs
Publication statusPublished - 2005

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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    Grimaldi, A., Barletta, A., Rascente, M., Pisani, F., Iaria, G., MacCarone, D., Maira, E., D'Angelo, M., & Famulari, A. (2005). Infectious complications in the renal transplant recipient. Transplantation Proceedings, 37(6), 2502-2503. https://doi.org/10.1016/j.transproceed.2005.06.009