Abstract
In children, infectious discitis (D) and infectious spondylodiscitis (SD) are rare diseases that can cause significant clinical problems, including spinal deformities and segmental instabilities. Moreover, when the infection spreads into the spinal channel, D and SD can cause devastating neurologic complications. Early diagnosis and treatment may reduce these risks. The main aim of this paper is to discuss recent concepts regarding the epidemiology, microbiology, clinical presentation, diagnosis, and treatment of pediatric D and SD. It is highlighted that particular attention must be paid to the identification of the causative infectious agent and its sensitivity to antibiotics, remembering that traditional culture frequently leads to negative results and modern molecular methods can significantly increase the detection rate. Several different bacterial pathogens can cause D and SD, and, in some cases, particularly those due to Staphylococcus aureus, Kingella kingae, Mycobacterium tuberculosis, Brucella spp., the appropriate choice of drug is critical to achieve cure.
| Original language | English |
|---|---|
| Article number | 539 |
| Journal | International Journal of Molecular Sciences |
| Volume | 17 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 9 2016 |
Fingerprint
Keywords
- Discitis
- Osteoarticular infections
- Pediatric orthopedics
- Spondylodiscitis
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry
- Spectroscopy
- Inorganic Chemistry
- Catalysis
- Molecular Biology
- Computer Science Applications
Cite this
Infectious discitis and spondylodiscitis in children. / Principi, Nicola; Esposito, Susanna.
In: International Journal of Molecular Sciences, Vol. 17, No. 4, 539, 09.04.2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Infectious discitis and spondylodiscitis in children
AU - Principi, Nicola
AU - Esposito, Susanna
PY - 2016/4/9
Y1 - 2016/4/9
N2 - In children, infectious discitis (D) and infectious spondylodiscitis (SD) are rare diseases that can cause significant clinical problems, including spinal deformities and segmental instabilities. Moreover, when the infection spreads into the spinal channel, D and SD can cause devastating neurologic complications. Early diagnosis and treatment may reduce these risks. The main aim of this paper is to discuss recent concepts regarding the epidemiology, microbiology, clinical presentation, diagnosis, and treatment of pediatric D and SD. It is highlighted that particular attention must be paid to the identification of the causative infectious agent and its sensitivity to antibiotics, remembering that traditional culture frequently leads to negative results and modern molecular methods can significantly increase the detection rate. Several different bacterial pathogens can cause D and SD, and, in some cases, particularly those due to Staphylococcus aureus, Kingella kingae, Mycobacterium tuberculosis, Brucella spp., the appropriate choice of drug is critical to achieve cure.
AB - In children, infectious discitis (D) and infectious spondylodiscitis (SD) are rare diseases that can cause significant clinical problems, including spinal deformities and segmental instabilities. Moreover, when the infection spreads into the spinal channel, D and SD can cause devastating neurologic complications. Early diagnosis and treatment may reduce these risks. The main aim of this paper is to discuss recent concepts regarding the epidemiology, microbiology, clinical presentation, diagnosis, and treatment of pediatric D and SD. It is highlighted that particular attention must be paid to the identification of the causative infectious agent and its sensitivity to antibiotics, remembering that traditional culture frequently leads to negative results and modern molecular methods can significantly increase the detection rate. Several different bacterial pathogens can cause D and SD, and, in some cases, particularly those due to Staphylococcus aureus, Kingella kingae, Mycobacterium tuberculosis, Brucella spp., the appropriate choice of drug is critical to achieve cure.
KW - Discitis
KW - Osteoarticular infections
KW - Pediatric orthopedics
KW - Spondylodiscitis
UR - http://www.scopus.com/inward/record.url?scp=84963570173&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84963570173&partnerID=8YFLogxK
U2 - 10.3390/ijms17040539
DO - 10.3390/ijms17040539
M3 - Article
AN - SCOPUS:84963570173
VL - 17
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1661-6596
IS - 4
M1 - 539
ER -