Infectious diseases and type 1 diabetes in children

Maria Teresa Tenconi, Miryam Martinetti

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Type 1 diabetes (T1D) is an autoimmune disease triggered by environmental factors. Among those of infectious origin, viruses mostly associated to T1D are rubella virus, enteroviruses (Rotavirus, Coxackie B), Cytomegalovirus and mumps virus. The role of bacterial infections is still controversial, acting either as modulators or precipitating factors of an already started autoimmune process. Polymorphic genes of innate immunity, such as Toll-like receptors, nucleotide-binding oligomerization domain (NOD)1 and NOD2 and mannose-binding lectin (MBL) genes, did not show a strict association With T1D onset, while protein tyrosine phosphatase (PTPN22), cytotoxic T-lymphocyte antigen (CTLA)4 and natural killer cells immunoglobulin-like receptor (KIR) genes appear to play an important role. However, the adaptive immune response genes (HLA) still provide the major contribution to T1D susceptibility. Here, we review the mechanism by which microorganisms might induce autoimmunity.

Original languageEnglish
Pages (from-to)583-594
Number of pages12
JournalPediatric Health
Volume2
Issue number5
DOIs
Publication statusPublished - 2008

Fingerprint

Type 1 Diabetes Mellitus
Communicable Diseases
Genes
KIR Receptors
CTLA-4 Antigen
Mumps virus
Rubella virus
Mannose-Binding Lectin
Cercopithecine Herpesvirus 1
Precipitating Factors
Protein Tyrosine Phosphatases
Enterovirus
Rotavirus
Toll-Like Receptors
Adaptive Immunity
Cytomegalovirus
Autoimmunity
Bacterial Infections
Innate Immunity
Natural Killer Cells

Keywords

  • Adaptive immunity
  • Epidemiology
  • Infections
  • Innate immunity
  • Type 1 diabetes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pediatrics

Cite this

Infectious diseases and type 1 diabetes in children. / Tenconi, Maria Teresa; Martinetti, Miryam.

In: Pediatric Health, Vol. 2, No. 5, 2008, p. 583-594.

Research output: Contribution to journalArticle

Tenconi, Maria Teresa ; Martinetti, Miryam. / Infectious diseases and type 1 diabetes in children. In: Pediatric Health. 2008 ; Vol. 2, No. 5. pp. 583-594.
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