Infective Endocarditis in Children in Italy from 2000 to 2015

Susanna Esposito, Alessandra Mayer, Andrzej Krzysztofiak, Silvia Garazzino, Rita Lipreri, Luisa Galli, Patrizia Osimani, Emilio Fossali, Maria Di Gangi, Laura Lancella, Marco Denina, Giulia Pattarino, Carlotta Montagnani, Filippo Salvini, Alberto Villani, Nicola Principi

Research output: Contribution to journalArticle

Abstract

Objective: The Italian Society for Pediatric Infectious Diseases created a registry on children with infective endocarditis (IE) hospitalized in Italy.Methods: A cross-sectional survey was conducted on patients hospitalized due to IE in Italian paediatric wards between January 1, 2000, and June 30, 2015.Results: Over the 15-year study period, 47 IE episodes were observed (19 males; age range, 2-17 years). Viridans Streptococci were the most common pathogens among patients with predisposing cardiac conditions and Staphylococcus aureus among those without (37.9% vs. 5.5%, p = 0.018, and 6.9% vs. 27.8%, p = 0.089, respectively). Six of the 7 (85.7%) S. aureus strains were methicillin-resistant. The majority of patients with and without predisposing cardiac conditions recovered without any complications.Conclusion: In Italy, paediatric IE develops without any previous predisposing factors in a number of children, methicillin-resistant S. aureus has emerged as a common causative agent and the therapeutic approach is extremely variable.

Original languageEnglish
Pages (from-to)353-358
Number of pages6
JournalExpert Review of Anti-Infective Therapy
Volume14
Issue number3
DOIs
Publication statusPublished - Mar 3 2016

Fingerprint

Endocarditis
Italy
Pediatrics
Staphylococcus aureus
Viridans Streptococci
Methicillin Resistance
Methicillin-Resistant Staphylococcus aureus
Causality
Communicable Diseases
Registries
Cross-Sectional Studies
Therapeutics

Keywords

  • anti-infective therapy
  • antibiotics
  • congenital heart disease
  • infective endocarditis
  • Staphylococcus aureus
  • viridans Streptococci

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)
  • Microbiology
  • Virology

Cite this

Esposito, S., Mayer, A., Krzysztofiak, A., Garazzino, S., Lipreri, R., Galli, L., ... Principi, N. (2016). Infective Endocarditis in Children in Italy from 2000 to 2015. Expert Review of Anti-Infective Therapy, 14(3), 353-358. https://doi.org/10.1586/14787210.2016.1136787

Infective Endocarditis in Children in Italy from 2000 to 2015. / Esposito, Susanna; Mayer, Alessandra; Krzysztofiak, Andrzej; Garazzino, Silvia; Lipreri, Rita; Galli, Luisa; Osimani, Patrizia; Fossali, Emilio; Di Gangi, Maria; Lancella, Laura; Denina, Marco; Pattarino, Giulia; Montagnani, Carlotta; Salvini, Filippo; Villani, Alberto; Principi, Nicola.

In: Expert Review of Anti-Infective Therapy, Vol. 14, No. 3, 03.03.2016, p. 353-358.

Research output: Contribution to journalArticle

Esposito, S, Mayer, A, Krzysztofiak, A, Garazzino, S, Lipreri, R, Galli, L, Osimani, P, Fossali, E, Di Gangi, M, Lancella, L, Denina, M, Pattarino, G, Montagnani, C, Salvini, F, Villani, A & Principi, N 2016, 'Infective Endocarditis in Children in Italy from 2000 to 2015', Expert Review of Anti-Infective Therapy, vol. 14, no. 3, pp. 353-358. https://doi.org/10.1586/14787210.2016.1136787
Esposito, Susanna ; Mayer, Alessandra ; Krzysztofiak, Andrzej ; Garazzino, Silvia ; Lipreri, Rita ; Galli, Luisa ; Osimani, Patrizia ; Fossali, Emilio ; Di Gangi, Maria ; Lancella, Laura ; Denina, Marco ; Pattarino, Giulia ; Montagnani, Carlotta ; Salvini, Filippo ; Villani, Alberto ; Principi, Nicola. / Infective Endocarditis in Children in Italy from 2000 to 2015. In: Expert Review of Anti-Infective Therapy. 2016 ; Vol. 14, No. 3. pp. 353-358.
@article{c2279d23ece04566bbd2e26e07e52c20,
title = "Infective Endocarditis in Children in Italy from 2000 to 2015",
abstract = "Objective: The Italian Society for Pediatric Infectious Diseases created a registry on children with infective endocarditis (IE) hospitalized in Italy.Methods: A cross-sectional survey was conducted on patients hospitalized due to IE in Italian paediatric wards between January 1, 2000, and June 30, 2015.Results: Over the 15-year study period, 47 IE episodes were observed (19 males; age range, 2-17 years). Viridans Streptococci were the most common pathogens among patients with predisposing cardiac conditions and Staphylococcus aureus among those without (37.9{\%} vs. 5.5{\%}, p = 0.018, and 6.9{\%} vs. 27.8{\%}, p = 0.089, respectively). Six of the 7 (85.7{\%}) S. aureus strains were methicillin-resistant. The majority of patients with and without predisposing cardiac conditions recovered without any complications.Conclusion: In Italy, paediatric IE develops without any previous predisposing factors in a number of children, methicillin-resistant S. aureus has emerged as a common causative agent and the therapeutic approach is extremely variable.",
keywords = "anti-infective therapy, antibiotics, congenital heart disease, infective endocarditis, Staphylococcus aureus, viridans Streptococci",
author = "Susanna Esposito and Alessandra Mayer and Andrzej Krzysztofiak and Silvia Garazzino and Rita Lipreri and Luisa Galli and Patrizia Osimani and Emilio Fossali and {Di Gangi}, Maria and Laura Lancella and Marco Denina and Giulia Pattarino and Carlotta Montagnani and Filippo Salvini and Alberto Villani and Nicola Principi",
year = "2016",
month = "3",
day = "3",
doi = "10.1586/14787210.2016.1136787",
language = "English",
volume = "14",
pages = "353--358",
journal = "Expert Review of Anti-Infective Therapy",
issn = "1478-7210",
publisher = "Taylor and Francis Ltd.",
number = "3",

}

TY - JOUR

T1 - Infective Endocarditis in Children in Italy from 2000 to 2015

AU - Esposito, Susanna

AU - Mayer, Alessandra

AU - Krzysztofiak, Andrzej

AU - Garazzino, Silvia

AU - Lipreri, Rita

AU - Galli, Luisa

AU - Osimani, Patrizia

AU - Fossali, Emilio

AU - Di Gangi, Maria

AU - Lancella, Laura

AU - Denina, Marco

AU - Pattarino, Giulia

AU - Montagnani, Carlotta

AU - Salvini, Filippo

AU - Villani, Alberto

AU - Principi, Nicola

PY - 2016/3/3

Y1 - 2016/3/3

N2 - Objective: The Italian Society for Pediatric Infectious Diseases created a registry on children with infective endocarditis (IE) hospitalized in Italy.Methods: A cross-sectional survey was conducted on patients hospitalized due to IE in Italian paediatric wards between January 1, 2000, and June 30, 2015.Results: Over the 15-year study period, 47 IE episodes were observed (19 males; age range, 2-17 years). Viridans Streptococci were the most common pathogens among patients with predisposing cardiac conditions and Staphylococcus aureus among those without (37.9% vs. 5.5%, p = 0.018, and 6.9% vs. 27.8%, p = 0.089, respectively). Six of the 7 (85.7%) S. aureus strains were methicillin-resistant. The majority of patients with and without predisposing cardiac conditions recovered without any complications.Conclusion: In Italy, paediatric IE develops without any previous predisposing factors in a number of children, methicillin-resistant S. aureus has emerged as a common causative agent and the therapeutic approach is extremely variable.

AB - Objective: The Italian Society for Pediatric Infectious Diseases created a registry on children with infective endocarditis (IE) hospitalized in Italy.Methods: A cross-sectional survey was conducted on patients hospitalized due to IE in Italian paediatric wards between January 1, 2000, and June 30, 2015.Results: Over the 15-year study period, 47 IE episodes were observed (19 males; age range, 2-17 years). Viridans Streptococci were the most common pathogens among patients with predisposing cardiac conditions and Staphylococcus aureus among those without (37.9% vs. 5.5%, p = 0.018, and 6.9% vs. 27.8%, p = 0.089, respectively). Six of the 7 (85.7%) S. aureus strains were methicillin-resistant. The majority of patients with and without predisposing cardiac conditions recovered without any complications.Conclusion: In Italy, paediatric IE develops without any previous predisposing factors in a number of children, methicillin-resistant S. aureus has emerged as a common causative agent and the therapeutic approach is extremely variable.

KW - anti-infective therapy

KW - antibiotics

KW - congenital heart disease

KW - infective endocarditis

KW - Staphylococcus aureus

KW - viridans Streptococci

UR - http://www.scopus.com/inward/record.url?scp=84958934044&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84958934044&partnerID=8YFLogxK

U2 - 10.1586/14787210.2016.1136787

DO - 10.1586/14787210.2016.1136787

M3 - Article

AN - SCOPUS:84958934044

VL - 14

SP - 353

EP - 358

JO - Expert Review of Anti-Infective Therapy

JF - Expert Review of Anti-Infective Therapy

SN - 1478-7210

IS - 3

ER -