Infective Endocarditis in Children in Italy from 2000 to 2015

Susanna Esposito, A. Mayer, Andrzej Krzysztofiak, Silvia Garazzino, R. Lipreri, Luisa Galli, P. Osimani, Emilio Fossali, Maria Di Gangi, Laura Lancella, Marco Denina, Giulia Pattarino, Carlotta Montagnani, F. Salvini, Alberto Villani, Nicola Principi

Research output: Contribution to journalArticlepeer-review


Objective: The Italian Society for Pediatric Infectious Diseases created a registry on children with infective endocarditis (IE) hospitalized in Italy.Methods: A cross-sectional survey was conducted on patients hospitalized due to IE in Italian paediatric wards between January 1, 2000, and June 30, 2015.Results: Over the 15-year study period, 47 IE episodes were observed (19 males; age range, 2-17 years). Viridans Streptococci were the most common pathogens among patients with predisposing cardiac conditions and Staphylococcus aureus among those without (37.9% vs. 5.5%, p = 0.018, and 6.9% vs. 27.8%, p = 0.089, respectively). Six of the 7 (85.7%) S. aureus strains were methicillin-resistant. The majority of patients with and without predisposing cardiac conditions recovered without any complications.Conclusion: In Italy, paediatric IE develops without any previous predisposing factors in a number of children, methicillin-resistant S. aureus has emerged as a common causative agent and the therapeutic approach is extremely variable.

Original languageEnglish
Pages (from-to)353-358
Number of pages6
JournalExpert Review of Anti-Infective Therapy
Issue number3
Publication statusPublished - Mar 3 2016


  • anti-infective therapy
  • antibiotics
  • congenital heart disease
  • infective endocarditis
  • Staphylococcus aureus
  • viridans Streptococci

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)
  • Microbiology
  • Virology

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