TY - JOUR
T1 - Infective Endocarditis in Children in Italy from 2000 to 2015
AU - Esposito, Susanna
AU - Mayer, A.
AU - Krzysztofiak, Andrzej
AU - Garazzino, Silvia
AU - Lipreri, R.
AU - Galli, Luisa
AU - Osimani, P.
AU - Fossali, Emilio
AU - Di Gangi, Maria
AU - Lancella, Laura
AU - Denina, Marco
AU - Pattarino, Giulia
AU - Montagnani, Carlotta
AU - Salvini, F.
AU - Villani, Alberto
AU - Principi, Nicola
PY - 2016/3/3
Y1 - 2016/3/3
N2 - Objective: The Italian Society for Pediatric Infectious Diseases created a registry on children with infective endocarditis (IE) hospitalized in Italy.Methods: A cross-sectional survey was conducted on patients hospitalized due to IE in Italian paediatric wards between January 1, 2000, and June 30, 2015.Results: Over the 15-year study period, 47 IE episodes were observed (19 males; age range, 2-17 years). Viridans Streptococci were the most common pathogens among patients with predisposing cardiac conditions and Staphylococcus aureus among those without (37.9% vs. 5.5%, p = 0.018, and 6.9% vs. 27.8%, p = 0.089, respectively). Six of the 7 (85.7%) S. aureus strains were methicillin-resistant. The majority of patients with and without predisposing cardiac conditions recovered without any complications.Conclusion: In Italy, paediatric IE develops without any previous predisposing factors in a number of children, methicillin-resistant S. aureus has emerged as a common causative agent and the therapeutic approach is extremely variable.
AB - Objective: The Italian Society for Pediatric Infectious Diseases created a registry on children with infective endocarditis (IE) hospitalized in Italy.Methods: A cross-sectional survey was conducted on patients hospitalized due to IE in Italian paediatric wards between January 1, 2000, and June 30, 2015.Results: Over the 15-year study period, 47 IE episodes were observed (19 males; age range, 2-17 years). Viridans Streptococci were the most common pathogens among patients with predisposing cardiac conditions and Staphylococcus aureus among those without (37.9% vs. 5.5%, p = 0.018, and 6.9% vs. 27.8%, p = 0.089, respectively). Six of the 7 (85.7%) S. aureus strains were methicillin-resistant. The majority of patients with and without predisposing cardiac conditions recovered without any complications.Conclusion: In Italy, paediatric IE develops without any previous predisposing factors in a number of children, methicillin-resistant S. aureus has emerged as a common causative agent and the therapeutic approach is extremely variable.
KW - anti-infective therapy
KW - antibiotics
KW - congenital heart disease
KW - infective endocarditis
KW - Staphylococcus aureus
KW - viridans Streptococci
UR - http://www.scopus.com/inward/record.url?scp=84958934044&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84958934044&partnerID=8YFLogxK
U2 - 10.1586/14787210.2016.1136787
DO - 10.1586/14787210.2016.1136787
M3 - Article
VL - 14
SP - 353
EP - 358
JO - Expert Review of Anti-Infective Therapy
JF - Expert Review of Anti-Infective Therapy
SN - 1478-7210
IS - 3
ER -