Abstract
To obtain a more integrated understanding of the different breast cancer phenotypes and to investigate whether biomolecular profiles can distinguish between specific histotypes, we explored the interrelations among several biologic variables indicative of, or related to, hormone dependence, proliferation and apoptosis control, and angiogenesis in ductal and lobular carcinomas, the most common histotypes. Oestrogen and progesterone receptors, tumour proliferative activity, the expression of cyclin A, p16ink4A, p27kip1, p21waf1, p53, bcl-2, and levels of vascular endothelial growth factor and hypoxia-inducible factor-1 α (HIF-1 α) were evaluated in 190 in ductal and 67 lobular carcinomas. Our findings support the hypothesis that in ductal and lobular carcinomas are two distinct, partially phenotypically unrelated entities, the latter being characterised by the presence of features indicative of differentiation such as oestrogen receptors, low proliferation and lack of p53 expression and associated with low vascular endothelial growth factor content compared to angiogenesis in ductal carcinomas. Conversely, no significant difference was found between lobular carcinomas and in ductal carcinomas considering the frequency distribution of PgR-positive cases, cyclin-dependent kinase inhibitors acting at the G I/S boundary, bcl-2 and HIF-1 α protein expression. Although both generally defined as hormone responsive, in ductal and lobular carcinomas are also characterised by biologic patterns in which proteins related to hormone responsiveness, cell-cycle control, apoptosis and angiogenesis were differently associated. This finding suggests the need to refine breast cancer characterisation in order to provide detailed information about individual tumours, or subsets of tumours, that will help in defining optimal treatment approaches.
| Original language | English |
|---|---|
| Pages (from-to) | 1105-1111 |
| Number of pages | 7 |
| Journal | British Journal of Cancer |
| Volume | 87 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Nov 4 2002 |
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Keywords
- Angiogenesis
- Apoptosis
- Ductal carcinoma
- Hormone responsiveness
- Lobular carcinoma
- Proliferation
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Infiltrating ductal and lobular breast carcinomas are characterised by different interrelationships among markers related to angiogenesis and hormone dependence. / Coradini, Danila; Pellizzaro, C.; Veneroni, S.; Ventura, L.; Daidone, M. G.
In: British Journal of Cancer, Vol. 87, No. 10, 04.11.2002, p. 1105-1111.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Infiltrating ductal and lobular breast carcinomas are characterised by different interrelationships among markers related to angiogenesis and hormone dependence
AU - Coradini, Danila
AU - Pellizzaro, C.
AU - Veneroni, S.
AU - Ventura, L.
AU - Daidone, M. G.
PY - 2002/11/4
Y1 - 2002/11/4
N2 - To obtain a more integrated understanding of the different breast cancer phenotypes and to investigate whether biomolecular profiles can distinguish between specific histotypes, we explored the interrelations among several biologic variables indicative of, or related to, hormone dependence, proliferation and apoptosis control, and angiogenesis in ductal and lobular carcinomas, the most common histotypes. Oestrogen and progesterone receptors, tumour proliferative activity, the expression of cyclin A, p16ink4A, p27kip1, p21waf1, p53, bcl-2, and levels of vascular endothelial growth factor and hypoxia-inducible factor-1 α (HIF-1 α) were evaluated in 190 in ductal and 67 lobular carcinomas. Our findings support the hypothesis that in ductal and lobular carcinomas are two distinct, partially phenotypically unrelated entities, the latter being characterised by the presence of features indicative of differentiation such as oestrogen receptors, low proliferation and lack of p53 expression and associated with low vascular endothelial growth factor content compared to angiogenesis in ductal carcinomas. Conversely, no significant difference was found between lobular carcinomas and in ductal carcinomas considering the frequency distribution of PgR-positive cases, cyclin-dependent kinase inhibitors acting at the G I/S boundary, bcl-2 and HIF-1 α protein expression. Although both generally defined as hormone responsive, in ductal and lobular carcinomas are also characterised by biologic patterns in which proteins related to hormone responsiveness, cell-cycle control, apoptosis and angiogenesis were differently associated. This finding suggests the need to refine breast cancer characterisation in order to provide detailed information about individual tumours, or subsets of tumours, that will help in defining optimal treatment approaches.
AB - To obtain a more integrated understanding of the different breast cancer phenotypes and to investigate whether biomolecular profiles can distinguish between specific histotypes, we explored the interrelations among several biologic variables indicative of, or related to, hormone dependence, proliferation and apoptosis control, and angiogenesis in ductal and lobular carcinomas, the most common histotypes. Oestrogen and progesterone receptors, tumour proliferative activity, the expression of cyclin A, p16ink4A, p27kip1, p21waf1, p53, bcl-2, and levels of vascular endothelial growth factor and hypoxia-inducible factor-1 α (HIF-1 α) were evaluated in 190 in ductal and 67 lobular carcinomas. Our findings support the hypothesis that in ductal and lobular carcinomas are two distinct, partially phenotypically unrelated entities, the latter being characterised by the presence of features indicative of differentiation such as oestrogen receptors, low proliferation and lack of p53 expression and associated with low vascular endothelial growth factor content compared to angiogenesis in ductal carcinomas. Conversely, no significant difference was found between lobular carcinomas and in ductal carcinomas considering the frequency distribution of PgR-positive cases, cyclin-dependent kinase inhibitors acting at the G I/S boundary, bcl-2 and HIF-1 α protein expression. Although both generally defined as hormone responsive, in ductal and lobular carcinomas are also characterised by biologic patterns in which proteins related to hormone responsiveness, cell-cycle control, apoptosis and angiogenesis were differently associated. This finding suggests the need to refine breast cancer characterisation in order to provide detailed information about individual tumours, or subsets of tumours, that will help in defining optimal treatment approaches.
KW - Angiogenesis
KW - Apoptosis
KW - Ductal carcinoma
KW - Hormone responsiveness
KW - Lobular carcinoma
KW - Proliferation
UR - http://www.scopus.com/inward/record.url?scp=0037021259&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037021259&partnerID=8YFLogxK
U2 - 10.1038/sj.bjc.6600556
DO - 10.1038/sj.bjc.6600556
M3 - Article
C2 - 12402149
AN - SCOPUS:0037021259
VL - 87
SP - 1105
EP - 1111
JO - British Journal of Cancer
JF - British Journal of Cancer
SN - 0007-0920
IS - 10
ER -