Infiltrating mast cells correlate with angiogenesis in bone metastases from gastric cancer patients

Michele Ammendola, Ilaria Marech, Giuseppe Sammarco, Valeria Zuccalà, Maria Luposella, Nicola Zizzo, Rosa Patruno, Alberto Crovace, Eustachio Ruggieri, Alfredo Francesco Zito, Cosmo Damiano Gadaleta, Rosario Sacco, Girolamo Ranieri

Research output: Contribution to journalArticlepeer-review

Abstract

While gastric cancer is a well established angiogenesis driven tumor, no data has been published regarding angiogenesis stimulated by mast cells (MCs) positive for tryptase in bone metastases from gastric cancer patients (BMGCP). It is well established that MCs play a role in immune responses and more recently it was demonstrated that MCs have been involved in tumor angiogenesis. We analyzed infiltrating MCs and neovascularization in BMGCP diagnosed by histology. A series of 15 stage T3-4N2-3M1 (by AJCC for Gastric Cancer Staging 7th Edition) BMGCP from bone biopsies were selected. Tumour tissue samples were evaluated by mean of immunohistochemistry and image analysis methods in terms of MCs density positive to tryptase (MCDPT), MCs area positive to tryptase (MCAPT), microvascular density (MVD) and endothelial area (EA). A significant correlation between MCDPT, MCAPT, MVD and EA groups to each other was found by Pearson and t-test analysis (r ranged from 0.68 to 0.82; p-value ranged from 0.00 to 0.02). Our very preliminary data suggest that infiltrating MCs positive for tryptase may play a role in BMGCP angiogenesis, and could be further evaluated as a novel target of anti-angiogenic therapy.

Original languageEnglish
Pages (from-to)3237-3250
Number of pages14
JournalInternational Journal of Molecular Sciences
Volume16
Issue number2
DOIs
Publication statusPublished - Feb 2 2015

Keywords

  • Anti-angiogenetic therapy
  • Bone metastases
  • Gastric cancer
  • Mast cells
  • Tryptase

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Computer Science Applications
  • Spectroscopy
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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