Infiltration of tumours by macrophages and dendritic cells: Tumour-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

Alberto Mantovani, Silvano Sozzani, Massimo Locati, Tiziana Schioppa, Alessandra Saccani, Paola Allavena, Antonio Sica

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Macrophages and dendritic cells infiltrate tumours. In the tumour microenvironment, mononuclear phagocytes acquire properties of polarized M2 (or alternatively activated) macrophages. These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumours, play a key role in subversion of adaptive immunity and in inflammatory circuits which promote tumour growth and progression.

Original languageEnglish
Title of host publicationNovartis Foundation Symposium
Pages137-145
Number of pages9
Volume256
Publication statusPublished - 2004

Publication series

NameNovartis Foundation Symposium
Volume256
ISSN (Print)15282511

ASJC Scopus subject areas

  • Medicine(all)

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