Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity

Massimo De Martinis; Claudio Franceschi; Daniela Monti; Lia Ginaldi

doi:10.1016/j.febslet.2005.02.055

Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity

Massimo De Martinis, Claudio Franceschi, Daniela Monti, Lia Ginaldi

Istituto Scienze Neurologiche

Research output: Contribution to journal › Article › peer-review

Abstract

Immunosenescence is the consequence of the continuous attrition caused by chronic antigenic stress. The most important characteristics of immunosenescence (accumulation of memory and effector T cells, reduction of naive T cells, shrinkage of T cell repertoire, reduction of the immunological space) are compatible with this assumption. Immunosenescence can be taken as proof that the beneficial effects of the immune system, devoted to the neutralization of harmful agents early in life, become detrimental late in life, in a period not foreseen by evolution. This perspective could explain the mechanisms of the ageing process as well as the pathogenesis of age-related diseases.

Original language	English
Pages (from-to)	2035-2039
Number of pages	5
Journal	FEBS Letters
Volume	579
Issue number	10
DOIs	https://doi.org/10.1016/j.febslet.2005.02.055
Publication status	Published - Apr 11 2005

Keywords

Age-related diseases
Ageing rate
Antigenic load
Immunosenescence
Inflamm-ageing

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

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10.1016/j.febslet.2005.02.055

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abstract = "Immunosenescence is the consequence of the continuous attrition caused by chronic antigenic stress. The most important characteristics of immunosenescence (accumulation of memory and effector T cells, reduction of naive T cells, shrinkage of T cell repertoire, reduction of the immunological space) are compatible with this assumption. Immunosenescence can be taken as proof that the beneficial effects of the immune system, devoted to the neutralization of harmful agents early in life, become detrimental late in life, in a period not foreseen by evolution. This perspective could explain the mechanisms of the ageing process as well as the pathogenesis of age-related diseases.",

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AU - Franceschi, Claudio

AU - Monti, Daniela

AU - Ginaldi, Lia

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AB - Immunosenescence is the consequence of the continuous attrition caused by chronic antigenic stress. The most important characteristics of immunosenescence (accumulation of memory and effector T cells, reduction of naive T cells, shrinkage of T cell repertoire, reduction of the immunological space) are compatible with this assumption. Immunosenescence can be taken as proof that the beneficial effects of the immune system, devoted to the neutralization of harmful agents early in life, become detrimental late in life, in a period not foreseen by evolution. This perspective could explain the mechanisms of the ageing process as well as the pathogenesis of age-related diseases.

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KW - Antigenic load

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KW - Inflamm-ageing

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Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity

Abstract

Keywords

ASJC Scopus subject areas

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