TY - JOUR
T1 - Inflamm-aging, cytokines and aging
T2 - State of the art, new hypotheses on the role of mitochondria and new perspectives from systems biology
AU - Salvioli, Stefano
AU - Capri, M.
AU - Valensin, S.
AU - Tieri, P.
AU - Monti, D.
AU - Ottaviani, E.
AU - Franceschi, C.
PY - 2006/8
Y1 - 2006/8
N2 - In this article we summarise present knowledge on the role of pro-inflammatory cytokines on chronic inflammation leading to organismal aging, a phenomenon we proposed to call "inflamm-aging". In particular, we review genetic data regarding polymorphisms of genes encoding for cytokines and proteins involved in natural immunity (such as Toll-like Receptors and Heat Shock Proteins) obtained from large population studies including young, old and very old people in good health status or affected by age-related diseases such as Alzheimer's Disease and Type II Diabetes. On the whole, despite some controversial results, the available data are in favour of the hypothesis that pro-inflammatory cytokines play an important role in aging and longevity. Further, we present a possible hypothesis to reconcile energetic dysfunction, including mitochondria, and inflamm-aging. New perspectives for future studies, including phylogenetic studies in animal models and in silico studies on mathematical and bioinformatic models inspired by the systems biology approach, are also proposed.
AB - In this article we summarise present knowledge on the role of pro-inflammatory cytokines on chronic inflammation leading to organismal aging, a phenomenon we proposed to call "inflamm-aging". In particular, we review genetic data regarding polymorphisms of genes encoding for cytokines and proteins involved in natural immunity (such as Toll-like Receptors and Heat Shock Proteins) obtained from large population studies including young, old and very old people in good health status or affected by age-related diseases such as Alzheimer's Disease and Type II Diabetes. On the whole, despite some controversial results, the available data are in favour of the hypothesis that pro-inflammatory cytokines play an important role in aging and longevity. Further, we present a possible hypothesis to reconcile energetic dysfunction, including mitochondria, and inflamm-aging. New perspectives for future studies, including phylogenetic studies in animal models and in silico studies on mathematical and bioinformatic models inspired by the systems biology approach, are also proposed.
KW - Aging
KW - Bioinformatics
KW - Cytokines
KW - Genetic polymorphisms
KW - Inflammation
KW - Mitochondria
KW - Systems biology
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U2 - 10.2174/138161206777947470
DO - 10.2174/138161206777947470
M3 - Article
C2 - 16918441
AN - SCOPUS:33747172229
VL - 12
SP - 3161
EP - 3171
JO - Current Pharmaceutical Design
JF - Current Pharmaceutical Design
SN - 1381-6128
IS - 24
ER -