TY - JOUR
T1 - Inflammaging and anti-inflammaging
T2 - A systemic perspective on aging and longevity emerged from studies in humans
AU - Franceschi, Claudio
AU - Capri, Miriam
AU - Monti, Daniela
AU - Giunta, Sergio
AU - Olivieri, Fabiola
AU - Sevini, Federica
AU - Panourgia, Maria Panagiota
AU - Invidia, Laura
AU - Celani, Laura
AU - Scurti, Maria
AU - Cevenini, Elisa
AU - Castellani, Gastone C.
AU - Salvioli, Stefano
PY - 2007/1
Y1 - 2007/1
N2 - A large part of the aging phenotype, including immunosenescence, is explained by an imbalance between inflammatory and anti-inflammatory networks, which results in the low grade chronic pro-inflammatory status we proposed to call inflammaging. Within this perspective, healthy aging and longevity are likely the result not only of a lower propensity to mount inflammatory responses but also of efficient anti-inflammatory networks, which in normal aging fail to fully neutralize the inflammatory processes consequent to the lifelong antigenic burden and exposure to damaging agents. Such a global imbalance can be a major driving force for frailty and common age-related pathologies, and should be addressed and studied within an evolutionary-based systems biology perspective. Evidence in favor of this conceptualization largely derives from studies in humans. We thus propose that inflammaging can be flanked by anti-inflammaging as major determinants not only of immunosenescence but eventually of global aging and longevity.
AB - A large part of the aging phenotype, including immunosenescence, is explained by an imbalance between inflammatory and anti-inflammatory networks, which results in the low grade chronic pro-inflammatory status we proposed to call inflammaging. Within this perspective, healthy aging and longevity are likely the result not only of a lower propensity to mount inflammatory responses but also of efficient anti-inflammatory networks, which in normal aging fail to fully neutralize the inflammatory processes consequent to the lifelong antigenic burden and exposure to damaging agents. Such a global imbalance can be a major driving force for frailty and common age-related pathologies, and should be addressed and studied within an evolutionary-based systems biology perspective. Evidence in favor of this conceptualization largely derives from studies in humans. We thus propose that inflammaging can be flanked by anti-inflammaging as major determinants not only of immunosenescence but eventually of global aging and longevity.
KW - Aging and longevity
KW - Human studies
KW - Inflammaging
KW - Inflammation and anti-inflammation
KW - Systems biology
UR - http://www.scopus.com/inward/record.url?scp=33846111415&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33846111415&partnerID=8YFLogxK
U2 - 10.1016/j.mad.2006.11.016
DO - 10.1016/j.mad.2006.11.016
M3 - Article
C2 - 17116321
AN - SCOPUS:33846111415
VL - 128
SP - 92
EP - 105
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
SN - 0047-6374
IS - 1
ER -