Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans

Claudio Franceschi, Miriam Capri, Daniela Monti, Sergio Giunta, Fabiola Olivieri, Federica Sevini, Maria Panagiota Panourgia, Laura Invidia, Laura Celani, Maria Scurti, Elisa Cevenini, Gastone C. Castellani, Stefano Salvioli

Research output: Contribution to journalArticlepeer-review

Abstract

A large part of the aging phenotype, including immunosenescence, is explained by an imbalance between inflammatory and anti-inflammatory networks, which results in the low grade chronic pro-inflammatory status we proposed to call inflammaging. Within this perspective, healthy aging and longevity are likely the result not only of a lower propensity to mount inflammatory responses but also of efficient anti-inflammatory networks, which in normal aging fail to fully neutralize the inflammatory processes consequent to the lifelong antigenic burden and exposure to damaging agents. Such a global imbalance can be a major driving force for frailty and common age-related pathologies, and should be addressed and studied within an evolutionary-based systems biology perspective. Evidence in favor of this conceptualization largely derives from studies in humans. We thus propose that inflammaging can be flanked by anti-inflammaging as major determinants not only of immunosenescence but eventually of global aging and longevity.

Original languageEnglish
Pages (from-to)92-105
Number of pages14
JournalMechanisms of Ageing and Development
Volume128
Issue number1
DOIs
Publication statusPublished - Jan 2007

Keywords

  • Aging and longevity
  • Human studies
  • Inflammaging
  • Inflammation and anti-inflammation
  • Systems biology

ASJC Scopus subject areas

  • Ageing
  • Biochemistry
  • Developmental Biology
  • Developmental Neuroscience

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