Inflammasome, T Lymphocytes and Innate-Adaptive Immunity Crosstalk: Role in Cardiovascular Disease and Therapeutic Perspectives

Daniela Pedicino, Ada Francesca Giglio, Aureliano Ruggio, Gianluca Massaro, Alessia D'Aiello, Francesco Trotta, Claudia Lucci, Francesca Graziani, Luigi Marzio Biasucci, Filippo Crea, Giovanna Liuzzo

Research output: Contribution to journalReview article

Abstract

Over the past few decades, lot of evidences have shown atherosclerosis as a chronic progressive disease with an exquisite inflammatory feature. More recently, the role of innate immune response in the onset and progression of coronary artery disease (CAD) and an adaptive immunity imbalance, mostly involving T cell sub-sets, have been documented. Therefore, like in many other inflammatory and autoimmune disorders, an altered innate-adaptive immunity crosstalk could represent the key of the inflammatory burden leading to atherosclerotic plaque formation and progression and to the breakdown of plaque stability. In this review, we will address the role of inflammasome in innate immunity and in the imbalance of adaptive immunity. We will discuss how this altered immune crosstalk is related to CAD onset and progression. We will also discuss how unravelling the key molecular mechanisms is of paramount importance in the development of therapeutic tools to delay the chronic progression and prevent the acute destabilization of atherosclerotic plaque.

Original languageEnglish
Pages (from-to)1352-1369
Number of pages18
JournalThrombosis and Haemostasis
Volume118
Issue number8
DOIs
Publication statusPublished - Aug 1 2018

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Keywords

  • acute coronary syndromes
  • adaptive immunity
  • coronary artery disease
  • inflammasome
  • innate immunity
  • precision medicine

ASJC Scopus subject areas

  • Hematology

Cite this

Pedicino, D., Giglio, A. F., Ruggio, A., Massaro, G., D'Aiello, A., Trotta, F., Lucci, C., Graziani, F., Biasucci, L. M., Crea, F., & Liuzzo, G. (2018). Inflammasome, T Lymphocytes and Innate-Adaptive Immunity Crosstalk: Role in Cardiovascular Disease and Therapeutic Perspectives. Thrombosis and Haemostasis, 118(8), 1352-1369. https://doi.org/10.1055/s-0038-1666860