TY - JOUR
T1 - Inflammasome, T Lymphocytes and Innate-Adaptive Immunity Crosstalk
T2 - Role in Cardiovascular Disease and Therapeutic Perspectives
AU - Pedicino, Daniela
AU - Giglio, Ada Francesca
AU - Ruggio, Aureliano
AU - Massaro, Gianluca
AU - D'Aiello, Alessia
AU - Trotta, Francesco
AU - Lucci, Claudia
AU - Graziani, Francesca
AU - Biasucci, Luigi Marzio
AU - Crea, Filippo
AU - Liuzzo, Giovanna
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Over the past few decades, lot of evidences have shown atherosclerosis as a chronic progressive disease with an exquisite inflammatory feature. More recently, the role of innate immune response in the onset and progression of coronary artery disease (CAD) and an adaptive immunity imbalance, mostly involving T cell sub-sets, have been documented. Therefore, like in many other inflammatory and autoimmune disorders, an altered innate-adaptive immunity crosstalk could represent the key of the inflammatory burden leading to atherosclerotic plaque formation and progression and to the breakdown of plaque stability. In this review, we will address the role of inflammasome in innate immunity and in the imbalance of adaptive immunity. We will discuss how this altered immune crosstalk is related to CAD onset and progression. We will also discuss how unravelling the key molecular mechanisms is of paramount importance in the development of therapeutic tools to delay the chronic progression and prevent the acute destabilization of atherosclerotic plaque.
AB - Over the past few decades, lot of evidences have shown atherosclerosis as a chronic progressive disease with an exquisite inflammatory feature. More recently, the role of innate immune response in the onset and progression of coronary artery disease (CAD) and an adaptive immunity imbalance, mostly involving T cell sub-sets, have been documented. Therefore, like in many other inflammatory and autoimmune disorders, an altered innate-adaptive immunity crosstalk could represent the key of the inflammatory burden leading to atherosclerotic plaque formation and progression and to the breakdown of plaque stability. In this review, we will address the role of inflammasome in innate immunity and in the imbalance of adaptive immunity. We will discuss how this altered immune crosstalk is related to CAD onset and progression. We will also discuss how unravelling the key molecular mechanisms is of paramount importance in the development of therapeutic tools to delay the chronic progression and prevent the acute destabilization of atherosclerotic plaque.
KW - acute coronary syndromes
KW - adaptive immunity
KW - coronary artery disease
KW - inflammasome
KW - innate immunity
KW - precision medicine
UR - http://www.scopus.com/inward/record.url?scp=85049857405&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85049857405&partnerID=8YFLogxK
U2 - 10.1055/s-0038-1666860
DO - 10.1055/s-0038-1666860
M3 - Review article
AN - SCOPUS:85049857405
VL - 118
SP - 1352
EP - 1369
JO - Thrombosis and Haemostasis
JF - Thrombosis and Haemostasis
SN - 0340-6245
IS - 8
ER -