Inflammation and antiangiogenesis in cancer

D. Ribatti, E. Crivellato, A. Vacca

Research output: Contribution to journalArticlepeer-review

Abstract

The immune system regulates angiogenesis in cancer by means of pro- and anti-angiogenesis activities. In fact, both innate (macrophages, granulocytes, mast cells, dendritic cells, natural killer cells, and platelets) and adaptive (T and B lymphocytes) immune cells synthesize several pro- and anti-angiogenic mediators. Moreover, in pre-clinical models, a synergy has been observed between antiangiogenic molecules and immunotherapy. In this review article, we will focus on some angiogenenic and anti-angiogenic molecules properties of immune cells that may be utilized for a potential parmacological use as anti-angiogenic agents in cancer.

Original languageEnglish
Pages (from-to)955-960
Number of pages6
JournalCurrent Medicinal Chemistry
Volume19
Issue number7
Publication statusPublished - Mar 2012

Keywords

  • Adaptive immunity
  • Angiogenesis
  • Anti-angiogenesis
  • Inflammation
  • Innate immunity
  • Lymphocytes
  • Macrophages
  • Mast cells
  • Neutrophils
  • Platelets
  • Tumor progression

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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