Inflammation and antiangiogenesis in cancer

D. Ribatti, E. Crivellato, A. Vacca

Research output: Contribution to journalArticle

Abstract

The immune system regulates angiogenesis in cancer by means of pro- and anti-angiogenesis activities. In fact, both innate (macrophages, granulocytes, mast cells, dendritic cells, natural killer cells, and platelets) and adaptive (T and B lymphocytes) immune cells synthesize several pro- and anti-angiogenic mediators. Moreover, in pre-clinical models, a synergy has been observed between antiangiogenic molecules and immunotherapy. In this review article, we will focus on some angiogenenic and anti-angiogenic molecules properties of immune cells that may be utilized for a potential parmacological use as anti-angiogenic agents in cancer.

Original languageEnglish
Pages (from-to)955-960
Number of pages6
JournalCurrent Medicinal Chemistry
Volume19
Issue number7
Publication statusPublished - Mar 2012

Fingerprint

Inflammation
Molecules
Lymphocytes
Macrophages
Immune system
Platelets
Granulocytes
Mast Cells
Natural Killer Cells
Immunotherapy
Dendritic Cells
Immune System
Neoplasms
B-Lymphocytes
Blood Platelets
T-Lymphocytes

Keywords

  • Adaptive immunity
  • Angiogenesis
  • Anti-angiogenesis
  • Inflammation
  • Innate immunity
  • Lymphocytes
  • Macrophages
  • Mast cells
  • Neutrophils
  • Platelets
  • Tumor progression

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Ribatti, D., Crivellato, E., & Vacca, A. (2012). Inflammation and antiangiogenesis in cancer. Current Medicinal Chemistry, 19(7), 955-960.

Inflammation and antiangiogenesis in cancer. / Ribatti, D.; Crivellato, E.; Vacca, A.

In: Current Medicinal Chemistry, Vol. 19, No. 7, 03.2012, p. 955-960.

Research output: Contribution to journalArticle

Ribatti, D, Crivellato, E & Vacca, A 2012, 'Inflammation and antiangiogenesis in cancer', Current Medicinal Chemistry, vol. 19, no. 7, pp. 955-960.
Ribatti D, Crivellato E, Vacca A. Inflammation and antiangiogenesis in cancer. Current Medicinal Chemistry. 2012 Mar;19(7):955-960.
Ribatti, D. ; Crivellato, E. ; Vacca, A. / Inflammation and antiangiogenesis in cancer. In: Current Medicinal Chemistry. 2012 ; Vol. 19, No. 7. pp. 955-960.
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