Abstract
Inflammation has long been suspected to contribute to tumor growth. However, the concept that oncogenes, known for decades as responsible for cell neoplastic transformation, build up an inflammatory pro-tumorigenic microenvironment is emerging only in the last few years. The well known oncogenes RAS and MYC have been causally linked to tumor angiogenesis through different ways. Moreover, in thyroid tumors, where many of the genetic tumor-initiating events have been identified, the oncogenes driving tumorigenesis were proved able to induce an inflammatory program. This minireview will focus on growing evidence implicating the role of intrinsic, oncogene-driven pathways leading to pro-tumoral inflammation.
| Original language | English |
|---|---|
| Pages (from-to) | 262-270 |
| Number of pages | 9 |
| Journal | Cancer Letters |
| Volume | 267 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Aug 28 2008 |
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Keywords
- Cancer
- Inflammation
- Oncogenes
ASJC Scopus subject areas
- Cancer Research
- Molecular Biology
- Oncology
Cite this
Inflammation and cancer : The oncogene-driven connection. / Borrello, Maria Grazia; Degl'Innocenti, Debora; Pierotti, Marco A.
In: Cancer Letters, Vol. 267, No. 2, 28.08.2008, p. 262-270.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inflammation and cancer
T2 - The oncogene-driven connection
AU - Borrello, Maria Grazia
AU - Degl'Innocenti, Debora
AU - Pierotti, Marco A.
PY - 2008/8/28
Y1 - 2008/8/28
N2 - Inflammation has long been suspected to contribute to tumor growth. However, the concept that oncogenes, known for decades as responsible for cell neoplastic transformation, build up an inflammatory pro-tumorigenic microenvironment is emerging only in the last few years. The well known oncogenes RAS and MYC have been causally linked to tumor angiogenesis through different ways. Moreover, in thyroid tumors, where many of the genetic tumor-initiating events have been identified, the oncogenes driving tumorigenesis were proved able to induce an inflammatory program. This minireview will focus on growing evidence implicating the role of intrinsic, oncogene-driven pathways leading to pro-tumoral inflammation.
AB - Inflammation has long been suspected to contribute to tumor growth. However, the concept that oncogenes, known for decades as responsible for cell neoplastic transformation, build up an inflammatory pro-tumorigenic microenvironment is emerging only in the last few years. The well known oncogenes RAS and MYC have been causally linked to tumor angiogenesis through different ways. Moreover, in thyroid tumors, where many of the genetic tumor-initiating events have been identified, the oncogenes driving tumorigenesis were proved able to induce an inflammatory program. This minireview will focus on growing evidence implicating the role of intrinsic, oncogene-driven pathways leading to pro-tumoral inflammation.
KW - Cancer
KW - Inflammation
KW - Oncogenes
UR - http://www.scopus.com/inward/record.url?scp=47749101220&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=47749101220&partnerID=8YFLogxK
U2 - 10.1016/j.canlet.2008.03.060
DO - 10.1016/j.canlet.2008.03.060
M3 - Article
C2 - 18502035
AN - SCOPUS:47749101220
VL - 267
SP - 262
EP - 270
JO - Cancer Letters
JF - Cancer Letters
SN - 0304-3835
IS - 2
ER -