Inflammation and host-pathogen interaction: Cause and consequence in cystic fibrosis lung disease

A Bragonzi, H Horati, L Kerrigan, NI Lorè, BJ Scholte, S Weldon

Research output: Contribution to journalArticle

Abstract

Cystic Fibrosis (CF) lung disease is associated with dysregulation of host defence systems, which ultimately disrupts the balance between inflammation and resolution and leaves the host susceptible to repeated infection. However, the mechanisms underlying these defects are complex and continue to garner significant interest among the CF research community. This review explores emerging data on novel aspects of innate host defence with promising biomarker and therapeutic potential for CF lung disease. Improved understanding of inflammation and host defence against pathogens in patients and animal models during the progression of CF lung disease is pivotal for the discovery of new therapeutics that can limit and/or prevent damage from birth. © 2017 European Cystic Fibrosis Society.
Original languageEnglish
Pages (from-to)S40–S45
JournalJournal of Cystic Fibrosis
Issue number17(2 Suppl
DOIs
Publication statusPublished - 2018

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