TY - JOUR
T1 - Inflammation and neurological adverse drugs reactions
T2 - A case of long lasting impaired consciousness after oxatomide administration in a patient with gastroenteritis
AU - Antoniazzi, Stefania
AU - Cattaneo, Dario
AU - Perrone, Valentina
AU - Carnovale, Carla
AU - Cherubini, Simonetta
AU - Mugolino, Maria Carmela
AU - Clementi, Francesco
AU - Zuccotti, Gianvincenzo
AU - Clementi, Emilio
AU - Radice, Sonia
PY - 2012
Y1 - 2012
N2 - Oxatomide at therapeutic doses generates occasionally drowsiness in children. When administered at toxic doses, however oxatomide may induce long lasting impaired consciousness. We now report a case of severe long lasting impaired consciousness induced by therapeutic doses of oxatomide occurring in a child affected by acute gastroenteritis. The clinical symptoms, the pharmacogenetic tests of polymorphisms in cytochrome P450 metabolizing enzymes (CYPs) and the clinical and laboratory analyses indicate that the enhanced drug sedative effect is likely due to an acute, yet mild, inflammatory state of the patient. These findings highlight the importance of assessing common, not serious inflammatory states when oxatomide is prescribed in paediatric patients.
AB - Oxatomide at therapeutic doses generates occasionally drowsiness in children. When administered at toxic doses, however oxatomide may induce long lasting impaired consciousness. We now report a case of severe long lasting impaired consciousness induced by therapeutic doses of oxatomide occurring in a child affected by acute gastroenteritis. The clinical symptoms, the pharmacogenetic tests of polymorphisms in cytochrome P450 metabolizing enzymes (CYPs) and the clinical and laboratory analyses indicate that the enhanced drug sedative effect is likely due to an acute, yet mild, inflammatory state of the patient. These findings highlight the importance of assessing common, not serious inflammatory states when oxatomide is prescribed in paediatric patients.
KW - Adverse drug reaction
KW - CYPs
KW - Inflammation
KW - Long lasting impaired consciousness
KW - Oxatomide
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U2 - 10.1186/1824-7288-38-11
DO - 10.1186/1824-7288-38-11
M3 - Article
C2 - 22464080
AN - SCOPUS:84860569842
VL - 38
JO - Italian Journal of Pediatrics
JF - Italian Journal of Pediatrics
SN - 1720-8424
IS - 1
M1 - 11
ER -