TY - JOUR
T1 - Inflammation and preterm birth
AU - Cappelletti, Monica
AU - Bella, Silvia Della
AU - Ferrazzi, Enrico
AU - Mavilio, Domenico
AU - Divanovic, Senad
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Preterm birth is the leading cause of neonatal morbidity and mortality. Although the underlying causes of pregnancy-associated complication are numerous, it is well established that infection and inflammation represent a highly significant risk factor in preterm birth. However, despite the clinical and public health significance, infectious agents, molecular trigger(s), and immune pathways underlying the pathogenesis of preterm birth remain underdefined and represent a major gap in knowledge. Here, we provide an overview of recent clinical and animal model data focused on the interplay between infection-driven inflammation and induction of preterm birth. Furthermore, here, we highlight the critical gaps in knowledge that warrant future investigations into the interplay between immune responses and induction of preterm birth.
AB - Preterm birth is the leading cause of neonatal morbidity and mortality. Although the underlying causes of pregnancy-associated complication are numerous, it is well established that infection and inflammation represent a highly significant risk factor in preterm birth. However, despite the clinical and public health significance, infectious agents, molecular trigger(s), and immune pathways underlying the pathogenesis of preterm birth remain underdefined and represent a major gap in knowledge. Here, we provide an overview of recent clinical and animal model data focused on the interplay between infection-driven inflammation and induction of preterm birth. Furthermore, here, we highlight the critical gaps in knowledge that warrant future investigations into the interplay between immune responses and induction of preterm birth.
KW - Cytokines
KW - Infection
KW - Innate immune cells
KW - Toll-like receptors
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U2 - 10.1189/jlb.3MR0615-272RR
DO - 10.1189/jlb.3MR0615-272RR
M3 - Article
C2 - 26538528
AN - SCOPUS:84953432453
VL - 99
SP - 67
EP - 78
JO - Journal of Leukocyte Biology
JF - Journal of Leukocyte Biology
SN - 0741-5400
IS - 1
ER -