Inflammation and prevention of epileptogenesis

Research output: Contribution to journalArticle

Abstract

CNS injuries such as trauma, stroke, viral infection, febrile seizures, status epilepticus occurring either in infancy or during a lifetime are considered common risk factors for developing epilepsy. Long term CNS inflammation develops rapidly after these events, suggesting that a pro-inflammatory state in the brain might play a role in the development of the epileptic process. This hypothesis is corroborated by two main lines of evidence: (1) the upregulation of pro-inflammatory signals during epileptogenesis in brain areas of seizure onset/generalization; (2) pharmacological targeting of specific pro-inflammatory pathways after status epilepticus or in kindling shows antiepileptogenic effects. The mechanisms by which pro-inflammatory molecules might favor the establishment of chronic neuronal network hyperexcitability involve both rapid, non-transcriptional effects on glutamate and GABA receptors, and transcriptional activation of genes involved in synaptic plasticity. This emerging evidence predicts that pharmacological interventions targeting brain inflammation might provide a key to new antiepileptic drug design.

Original languageEnglish
Pages (from-to)223-230
Number of pages8
JournalNeuroscience Letters
Volume497
Issue number3
DOIs
Publication statusPublished - Jun 27 2011

Keywords

  • Anti-inflammatory
  • Brain development
  • COX-2
  • Cytokines
  • Epilepsy
  • Interleukin
  • Lipopolysaccharide
  • Toll-like receptor

ASJC Scopus subject areas

  • Neuroscience(all)

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