Inflammation and primary graft dysfunction after lung transplantation

Miriam Gotti, Davide Chiumello, Massimo Cressoni, Mariateresa Guanziroli, Matteo Brioni, Bijan Safaee Fakhr, Chiara Chiurazzi, Andrea Colombo, Dario Massari, Ilaria Algieri, Caterina Lonati, Paolo Cadringher, Paolo Taccone, Marta Pizzocri, Jacopo Fumagalli, Lorenzo Rosso, Alessandro Palleschi, Riccardo Benti, Felicia Zito, Franco ValenzaLuciano Gattinoni

Research output: Contribution to journalArticle

Abstract

BACKGROUND: The leading cause of early mortality after lung transplantation is Primary graft dysfunction (PGD). We assessed the lung inflammation, inflation status and inhomogeneities after lung transplantation. Our purpose was to investigate the possible differences between patients who did or did not develop PGD.METHODS: We designed a prospective observational study enrolling patients who underwent a CT-PET study within 1 week after lung transplantation. Twenty-four patients (10 after double- and 14 after single-lung) were enrolled. Respiratory and hemodynamic data were collected before, during and after lung transplantation. Each patient underwent computed tomography-positron emission tomography (CT-PET) scan early after surgery. Broncho-alveolar lavage (BAL) fluid collection was performed to analyze inflammatory mediators.RESULTS: The grafts showed a [18F]fluoro-2-deoxy-D-glucose ([18F]FDG) uptake rate of 26[18-33]*10-4 mLblood/mLtissue/min (reference values 11[7-15]*10-4). Three double- and six single-lung recipients developed PGD. The grafts of patients who developed PGD had similar [18F]FDG uptake than grafts of patients who did not (28[18-26]*10-4 versus 26[22-31]*10-4, P=0.79). Not-inflated tissue fraction was significantly higher (28[20-38]% versus 14[7-21]%, P=0.01) while well-inflated fraction was significantly lower (29[25-41]% versus 53[39-65]%, P
Original languageEnglish
Pages (from-to)1169-1177
Number of pages9
JournalMinerva Anestesiologica
Volume84
Issue number10
Publication statusPublished - Oct 1 2018

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Primary Graft Dysfunction
Lung Transplantation
Inflammation
Transplants
Lung
Fluorodeoxyglucose F18
Economic Inflation
Deoxyglucose
Bronchoalveolar Lavage Fluid
Observational Studies
Pneumonia
Reference Values
Hemodynamics
Prospective Studies
Mortality

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Gotti, M., Chiumello, D., Cressoni, M., Guanziroli, M., Brioni, M., Safaee Fakhr, B., ... Gattinoni, L. (2018). Inflammation and primary graft dysfunction after lung transplantation. Minerva Anestesiologica, 84(10), 1169-1177.

Inflammation and primary graft dysfunction after lung transplantation. / Gotti, Miriam; Chiumello, Davide; Cressoni, Massimo; Guanziroli, Mariateresa; Brioni, Matteo; Safaee Fakhr, Bijan; Chiurazzi, Chiara; Colombo, Andrea; Massari, Dario; Algieri, Ilaria; Lonati, Caterina; Cadringher, Paolo; Taccone, Paolo; Pizzocri, Marta; Fumagalli, Jacopo; Rosso, Lorenzo; Palleschi, Alessandro; Benti, Riccardo; Zito, Felicia; Valenza, Franco; Gattinoni, Luciano.

In: Minerva Anestesiologica, Vol. 84, No. 10, 01.10.2018, p. 1169-1177.

Research output: Contribution to journalArticle

Gotti, M, Chiumello, D, Cressoni, M, Guanziroli, M, Brioni, M, Safaee Fakhr, B, Chiurazzi, C, Colombo, A, Massari, D, Algieri, I, Lonati, C, Cadringher, P, Taccone, P, Pizzocri, M, Fumagalli, J, Rosso, L, Palleschi, A, Benti, R, Zito, F, Valenza, F & Gattinoni, L 2018, 'Inflammation and primary graft dysfunction after lung transplantation', Minerva Anestesiologica, vol. 84, no. 10, pp. 1169-1177.
Gotti M, Chiumello D, Cressoni M, Guanziroli M, Brioni M, Safaee Fakhr B et al. Inflammation and primary graft dysfunction after lung transplantation. Minerva Anestesiologica. 2018 Oct 1;84(10):1169-1177.
Gotti, Miriam ; Chiumello, Davide ; Cressoni, Massimo ; Guanziroli, Mariateresa ; Brioni, Matteo ; Safaee Fakhr, Bijan ; Chiurazzi, Chiara ; Colombo, Andrea ; Massari, Dario ; Algieri, Ilaria ; Lonati, Caterina ; Cadringher, Paolo ; Taccone, Paolo ; Pizzocri, Marta ; Fumagalli, Jacopo ; Rosso, Lorenzo ; Palleschi, Alessandro ; Benti, Riccardo ; Zito, Felicia ; Valenza, Franco ; Gattinoni, Luciano. / Inflammation and primary graft dysfunction after lung transplantation. In: Minerva Anestesiologica. 2018 ; Vol. 84, No. 10. pp. 1169-1177.
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T1 - Inflammation and primary graft dysfunction after lung transplantation

AU - Gotti, Miriam

AU - Chiumello, Davide

AU - Cressoni, Massimo

AU - Guanziroli, Mariateresa

AU - Brioni, Matteo

AU - Safaee Fakhr, Bijan

AU - Chiurazzi, Chiara

AU - Colombo, Andrea

AU - Massari, Dario

AU - Algieri, Ilaria

AU - Lonati, Caterina

AU - Cadringher, Paolo

AU - Taccone, Paolo

AU - Pizzocri, Marta

AU - Fumagalli, Jacopo

AU - Rosso, Lorenzo

AU - Palleschi, Alessandro

AU - Benti, Riccardo

AU - Zito, Felicia

AU - Valenza, Franco

AU - Gattinoni, Luciano

PY - 2018/10/1

Y1 - 2018/10/1

N2 - BACKGROUND: The leading cause of early mortality after lung transplantation is Primary graft dysfunction (PGD). We assessed the lung inflammation, inflation status and inhomogeneities after lung transplantation. Our purpose was to investigate the possible differences between patients who did or did not develop PGD.METHODS: We designed a prospective observational study enrolling patients who underwent a CT-PET study within 1 week after lung transplantation. Twenty-four patients (10 after double- and 14 after single-lung) were enrolled. Respiratory and hemodynamic data were collected before, during and after lung transplantation. Each patient underwent computed tomography-positron emission tomography (CT-PET) scan early after surgery. Broncho-alveolar lavage (BAL) fluid collection was performed to analyze inflammatory mediators.RESULTS: The grafts showed a [18F]fluoro-2-deoxy-D-glucose ([18F]FDG) uptake rate of 26[18-33]*10-4 mLblood/mLtissue/min (reference values 11[7-15]*10-4). Three double- and six single-lung recipients developed PGD. The grafts of patients who developed PGD had similar [18F]FDG uptake than grafts of patients who did not (28[18-26]*10-4 versus 26[22-31]*10-4, P=0.79). Not-inflated tissue fraction was significantly higher (28[20-38]% versus 14[7-21]%, P=0.01) while well-inflated fraction was significantly lower (29[25-41]% versus 53[39-65]%, P

AB - BACKGROUND: The leading cause of early mortality after lung transplantation is Primary graft dysfunction (PGD). We assessed the lung inflammation, inflation status and inhomogeneities after lung transplantation. Our purpose was to investigate the possible differences between patients who did or did not develop PGD.METHODS: We designed a prospective observational study enrolling patients who underwent a CT-PET study within 1 week after lung transplantation. Twenty-four patients (10 after double- and 14 after single-lung) were enrolled. Respiratory and hemodynamic data were collected before, during and after lung transplantation. Each patient underwent computed tomography-positron emission tomography (CT-PET) scan early after surgery. Broncho-alveolar lavage (BAL) fluid collection was performed to analyze inflammatory mediators.RESULTS: The grafts showed a [18F]fluoro-2-deoxy-D-glucose ([18F]FDG) uptake rate of 26[18-33]*10-4 mLblood/mLtissue/min (reference values 11[7-15]*10-4). Three double- and six single-lung recipients developed PGD. The grafts of patients who developed PGD had similar [18F]FDG uptake than grafts of patients who did not (28[18-26]*10-4 versus 26[22-31]*10-4, P=0.79). Not-inflated tissue fraction was significantly higher (28[20-38]% versus 14[7-21]%, P=0.01) while well-inflated fraction was significantly lower (29[25-41]% versus 53[39-65]%, P

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JO - Minerva Anestesiologica

JF - Minerva Anestesiologica

SN - 0375-9393

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