Inflammation and rehabilitation outcomes in patients with nontraumatic intracranial haemorrhage

Mirella Boselli, Roberto Aquilani, Roberto Maestri, Maria Pia Achilli, Nadia Arrigoni, Evasio Pasini, Anna Maria Condino, Federica Boschi, Maurizia Dossena, Daniela Buonocore, Manuela Verri

Research output: Contribution to journalArticlepeer-review


BACKGROUND: Systemic inflammation and its impact on rehabilitation for patients with non-traumatic haemorrhagic injury (HBI) sequelae has not yet been adequately documented.

OBJECTIVE AND METHODS: We therefore considered 31 patients with HBI, to determine the serum levels of inflammatory markers (C-Reactive Protein, CRP and or interleukine-6, IL-6) to establish their impact on functional status (Functional Independence Measure, FIM: 18 indicating the worst performance and 126, a normal score).

RESULTS: The results showed an inflammation prevalence (CRP >0.5 mg/dl and/or IL 6 >7 pg/ml) of 74.2% at admission to Rehab. FIM reduction was more pronounced in inflamed compared to non-inflamed subjects (p <  0.05) and significantly correlated with blood variables sensitive to inflammation, such as alpha 1 globulin (r = - 0.565) and neutrophil/ lymphocyte ratio (r = - 0.52), CRP (r = - 0.365). At discharge from Rehab, the inflammation rate diminished. Inflamed patients showed similar gains in FIM score as their controls. In the entire population, the FIM gain was significantly associated with a gain in serum albumin, only (r = +0.56).

CONCLUSIONS: We conclude that systemic inflammation is prevalent in HBI patients and contributes to reduce patient functional status. However, during the Rehab stage, inflammation does not hinder the improvement rate of functional capacity.

Original languageEnglish
Pages (from-to)449-456
Number of pages8
Issue number4
Publication statusPublished - 2018


  • Aged
  • C-Reactive Protein/metabolism
  • Cytokines/blood
  • Female
  • Humans
  • Intracranial Hemorrhages/blood
  • Male
  • Middle Aged
  • Neurological Rehabilitation/statistics & numerical data
  • Treatment Outcome


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