Inflammation and restenosis after percutaneous coronary interventions

Konstantinos Toutouzas, Antonio Colombo, Christodoulos Stefanadis

Research output: Contribution to journalArticle

151 Citations (Scopus)

Abstract

The role of inflammation in the development of restenosis after percutaneous coronary interventions has been investigated in several studies. There is an interaction of inflammatory activation and vascular wall response to injury leading to intimal hyperplasia. Percutaneous interventions trigger inflammatory reactions leading to the development of intimal hyperplasia. This reaction is even more prominent in atheromatic plaques in which inflammatory cells have already been activated. In the clinical setting there are several methods for the recognition of the inflammatory activation. In this article we review the data for the role of inflammatory process in restenosis and the significance of identifying the inflamed lesions prior to the intervention. Moreover, the therapeutic implications for the inhibition of inflammatory activation are mentioned.

Original languageEnglish
Pages (from-to)1679-1687
Number of pages9
JournalEuropean Heart Journal
Volume25
Issue number19
DOIs
Publication statusPublished - Oct 2004

Fingerprint

Tunica Intima
Percutaneous Coronary Intervention
Hyperplasia
Inflammation
Blood Vessels
Wounds and Injuries
Therapeutics

Keywords

  • Angioplasty
  • Inflammation
  • Restenosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Inflammation and restenosis after percutaneous coronary interventions. / Toutouzas, Konstantinos; Colombo, Antonio; Stefanadis, Christodoulos.

In: European Heart Journal, Vol. 25, No. 19, 10.2004, p. 1679-1687.

Research output: Contribution to journalArticle

Toutouzas, Konstantinos ; Colombo, Antonio ; Stefanadis, Christodoulos. / Inflammation and restenosis after percutaneous coronary interventions. In: European Heart Journal. 2004 ; Vol. 25, No. 19. pp. 1679-1687.
@article{56aa0efc5ad04b478c4177dfd8789e22,
title = "Inflammation and restenosis after percutaneous coronary interventions",
abstract = "The role of inflammation in the development of restenosis after percutaneous coronary interventions has been investigated in several studies. There is an interaction of inflammatory activation and vascular wall response to injury leading to intimal hyperplasia. Percutaneous interventions trigger inflammatory reactions leading to the development of intimal hyperplasia. This reaction is even more prominent in atheromatic plaques in which inflammatory cells have already been activated. In the clinical setting there are several methods for the recognition of the inflammatory activation. In this article we review the data for the role of inflammatory process in restenosis and the significance of identifying the inflamed lesions prior to the intervention. Moreover, the therapeutic implications for the inhibition of inflammatory activation are mentioned.",
keywords = "Angioplasty, Inflammation, Restenosis",
author = "Konstantinos Toutouzas and Antonio Colombo and Christodoulos Stefanadis",
year = "2004",
month = "10",
doi = "10.1016/j.ehj.2004.06.011",
language = "English",
volume = "25",
pages = "1679--1687",
journal = "European Heart Journal",
issn = "0195-668X",
publisher = "Oxford University Press",
number = "19",

}

TY - JOUR

T1 - Inflammation and restenosis after percutaneous coronary interventions

AU - Toutouzas, Konstantinos

AU - Colombo, Antonio

AU - Stefanadis, Christodoulos

PY - 2004/10

Y1 - 2004/10

N2 - The role of inflammation in the development of restenosis after percutaneous coronary interventions has been investigated in several studies. There is an interaction of inflammatory activation and vascular wall response to injury leading to intimal hyperplasia. Percutaneous interventions trigger inflammatory reactions leading to the development of intimal hyperplasia. This reaction is even more prominent in atheromatic plaques in which inflammatory cells have already been activated. In the clinical setting there are several methods for the recognition of the inflammatory activation. In this article we review the data for the role of inflammatory process in restenosis and the significance of identifying the inflamed lesions prior to the intervention. Moreover, the therapeutic implications for the inhibition of inflammatory activation are mentioned.

AB - The role of inflammation in the development of restenosis after percutaneous coronary interventions has been investigated in several studies. There is an interaction of inflammatory activation and vascular wall response to injury leading to intimal hyperplasia. Percutaneous interventions trigger inflammatory reactions leading to the development of intimal hyperplasia. This reaction is even more prominent in atheromatic plaques in which inflammatory cells have already been activated. In the clinical setting there are several methods for the recognition of the inflammatory activation. In this article we review the data for the role of inflammatory process in restenosis and the significance of identifying the inflamed lesions prior to the intervention. Moreover, the therapeutic implications for the inhibition of inflammatory activation are mentioned.

KW - Angioplasty

KW - Inflammation

KW - Restenosis

UR - http://www.scopus.com/inward/record.url?scp=4644326910&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4644326910&partnerID=8YFLogxK

U2 - 10.1016/j.ehj.2004.06.011

DO - 10.1016/j.ehj.2004.06.011

M3 - Article

C2 - 15451145

AN - SCOPUS:4644326910

VL - 25

SP - 1679

EP - 1687

JO - European Heart Journal

JF - European Heart Journal

SN - 0195-668X

IS - 19

ER -