Inflammation and the mucosal microcirculation in inflammatory bowel disease: The ebb and flow

Research output: Contribution to journalArticle

Abstract

PURPOSE OF REVIEW: Inflammatory bowel disease pathogenesis involves the interplay of multiple biological factors, among which nonimmune cells, including the endothelium, represent a crucial component of disease pathogenesis. RECENT FINDINGS: Endothelial cells play a key role in chronic inflammation through multiple and disparate activities. The mucosal microvasculature in inflammatory bowel disease is dysfunctional, overexpresses inflammatory molecules and undergoes intense angiogenesis, failing to exert its physiological antiinflammatory and anticoagulant activities. SUMMARY: The mucosal microcirculation is abnormal in inflammatory bowel disease and represents a novel component of disease pathogenesis; targeting the various abnormalities of the inflammatory bowel disease microcirculation may lead to new forms of therapeutic intervention.

Original languageEnglish
Pages (from-to)384-389
Number of pages6
JournalCurrent Opinion in Gastroenterology
Volume23
Issue number4
DOIs
Publication statusPublished - Jul 2007

Keywords

  • Crohn's disease
  • Endothelium
  • Inflammatory bowel disease
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

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