Inflammation as a possible link between coronary and carotid plaque instability.

Antonella Lombardo, Luigi Marzio Biasucci, Gaetano Antonio Lanza, Stefano Coli, Pasquale Silvestri, Domenico Cianflone, Giovanna Liuzzo, Francesco Burzotta, Filippo Crea, Attilio Maseri

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Multiple complex stenoses, plaque fissures, and widespread coronary inflammation are common in acute coronary syndromes. A systemic cause of atherosclerotic plaque instability is also suggested by studies of ischemic cerebrovascular disease. We investigated the association between coronary and carotid plaque instability and the potential common causal role of inflammation. METHODS AND RESULTS: The ultrasound characteristics of carotid plaques were evaluated retrospectively in patients scheduled for coronary bypass surgery, 181 with unstable and 92 with stable angina, and prospectively in a similar group of patients, 67 with unstable and 25 with stable angina, in whom serum C-reactive protein levels were also measured. The prevalence of carotid plaques was similar in the retrospective and prospective studies and >64% in both unstable and stable coronary patients. The prevalence of complex, presumably unstable carotid plaques was 23.2% in unstable versus 3.2% in stable patients (P3 mg/L were independently associated with complex carotid plaques (OR, 6.09; 95% CI, 1.01 to 33.72; P=0.039, and OR, 5.80; 95% CI, 1.55 to 21.69; P=0.009, respectively). CONCLUSIONS: In unstable angina, plaque instability may not be confined to coronary arteries, and inflammation may be the common link with carotid plaque instability. These observations may have relevant implications for understanding the mechanisms of acute widespread atherothrombotic plaque inflammation.

Original languageEnglish
Pages (from-to)3158-3163
Number of pages6
JournalCirculation
Volume109
Issue number25
Publication statusPublished - Jun 29 2004

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Lombardo, A., Biasucci, L. M., Lanza, G. A., Coli, S., Silvestri, P., Cianflone, D., Liuzzo, G., Burzotta, F., Crea, F., & Maseri, A. (2004). Inflammation as a possible link between coronary and carotid plaque instability. Circulation, 109(25), 3158-3163.