Inflammation, HIF-1, and the epigenetics that follows

Claudio Brigati, Barbara Banelli, Angela Di Vinci, Ida Casciano, Giorgio Allemanni, Alessandra Forlani, Luana Borz, Massimo Romani

Research output: Contribution to journalArticlepeer-review


We summarize recent findings linking inflammatory hypoxia to chromatin modifications, in particular to repressive histone signatures. We focus on the role of Hypoxia-Induced Factor-1 in promoting the activity of specific histone demethylases thus deeply modifying chromatin configuration. The consequences of these changes are depicted in terms of gene expression and cellular phenotypes. We finally integrate available data to introduce novel speculations on the relationship between inflammation, histones, and DNA function and integrity.

Original languageEnglish
Article number263914
JournalMediators of Inflammation
Publication statusPublished - 2010

ASJC Scopus subject areas

  • Immunology
  • Cell Biology


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