Inflammation in Obesity-Related Complications in Children: The Protective Effect of Diet and Its Potential Role as a Therapeutic Agent

Valeria Calcaterra, Corrado Regalbuto, Debora Porri, Gloria Pelizzo, Emanuela Mazzon, Federica Vinci, Gianvincenzo Zuccotti, Valentina Fabiano, Hellas Cena

Research output: Contribution to journalReview articlepeer-review

Abstract

Obesity is a growing health problem in both children and adults, impairing physical and mental state and impacting health care system costs in both developed and developing countries. It is well-known that individuals with excessive weight gain frequently develop obesity-related complications, which are mainly known as Non-Communicable Diseases (NCDs), including cardiovascular disease, type 2 diabetes mellitus, metabolic syndrome, non-alcoholic fatty liver disease, hypertension, hyperlipidemia and many other risk factors proven to be associated with chronic inflammation, causing disability and reduced life expectancy. This review aims to present and discuss complications related to inflammation in pediatric obesity, the critical role of nutrition and diet in obesity-comorbidity prevention and treatment, and the impact of lifestyle. Appropriate early dietary intervention for the management of pediatric overweight and obesity is recommended for overall healthy growth and prevention of comorbidities in adulthood.

Original languageEnglish
Article number1324
JournalBiomolecules
Volume10
Issue number9
DOIs
Publication statusPublished - Sep 16 2020

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