Inflammation inhibits GABA transmission in multiple sclerosis

Silvia Rossi, Valeria Studer, Caterina Motta, Valentina De Chiara, Francesca Barbieri, Giorgio Bernardi, Diego Centonze

Research output: Contribution to journalArticle

Abstract

Abnormal glutamate-dependent synaptic excitation contributes to neuronal damage in multiple sclerosis (MS). Little is known about the involvement of the GABA system in this disorder. Here we found that cerebrospinal fluid (CSF) from MS patients with enhanced brain lesions on magnetic resonance imaging inhibited GABA transmission in mouse brain slices. Enhanced IL-1β neuronal action was responsible for this effect, because IL-1β receptor antagonist blocked, and exogenous IL-1β mimicked the synaptic effect of inflamed CSF. Our results provide evidence that focal inflammation in MS perturbs the cytokine milieu within the circulating CSF, resulting in diffuse GABAergic alteration in neurons.

Original languageEnglish
Pages (from-to)1633-1635
Number of pages3
JournalMultiple Sclerosis Journal
Volume18
Issue number11
DOIs
Publication statusPublished - 2012

Keywords

  • excitotoxicity
  • Glutamate
  • IL-1β
  • IPSC
  • neurodegeneration

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

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