Inflammation, insulin resistance, and obesity

Patrizia Ferroni, Stefani Basili, Angela Falco, Giovanni Davì

Research output: Contribution to journalArticlepeer-review


Obesity, in particular visceral obesity, has strong associations with cardiovascular disease and is related to many factors that are constituents of the metabolic syndrome. Increasing evidence suggests that features of the metabolic syndrome, including visceral obesity, are associated with a low-grade inflammatory state. Indeed, visceral fat is a source of several molecules, such as leptin, adiponectin, tumor necrosis factor-α, and interleukin 6, that are collectively called adipokines. All of them may induce a proinflammatory state and oxidative damage, leading to initiation and progression of atherosclerosis. Reduced-energy diets might represent an effective and healthful approach for long-term weight loss in patients with metabolic syndrome by reducing the underlying inflammatory condition.

Original languageEnglish
Pages (from-to)424-431
Number of pages8
JournalCurrent Atherosclerosis Reports
Issue number6
Publication statusPublished - Nov 2004

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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