Inflammation markers predicting frailty and mortality in the elderly

Massimo De Martinis, Claudio Franceschi, Daniela Monti, Lia Ginaldi

Research output: Contribution to journalArticlepeer-review


Greater numbers of individuals are living to older ages. A major concern at both individual and population levels is how to live these years at a high functional level. If we had physiological markers to identify those at risk for progressive functional decline and impeding death, therapies could be targeted towards these individuals to prevent adverse outcomes. Senescence is presently considered as the consequence of lifelong antigenic stress impinging upon the individual genetic background. We might consider inflammation markers as synthetic measures of lifelong attrition combined with genetic tendency to develop an inflammatory phenotype. Such biomarkers are the most powerful predictors of frailty and mortality in the elderly available today. The aim of this review is to translate results from the research on ageing into a practical view, suggesting new tools for the clinical approach to older people.

Original languageEnglish
Pages (from-to)219-227
Number of pages9
JournalExperimental and Molecular Pathology
Issue number3
Publication statusPublished - Jun 2006


  • Elderly
  • Frailty
  • Inflammation markers

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Biology
  • Pathology and Forensic Medicine


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