Inflammatory reactions of the gut mucosa occur as a normal response to the enormous variety of antigens present in the bowel lumen. In most cases there is an effective downregulation of the immune reaction leading to tissue reparation and institution of oral tolerance. Inflammatory bowel diseases are characterized by a severe alteration of mucosal immunoregulation that involves all the components of the immune system. A critical role is played by T-lymphocytes which determine the cytokine pattern and regulate the activity of other immune system cells. Induction and maintenance of mucosal inflammation in these type of diseases is probably the result of an abnormal immunological response to common antigens (bacterial products, drugs, dietary antigens) in genetic susceptible hosts.
|Number of pages||4|
|Issue number||SUPPL. 1|
|Publication status||Published - 1997|
- Inflammatory bowel disease
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