Inflammation of the bowel

R. Manna, M. Latteri, A. De Santis, A. Romito, P. Gemelli, G. Corazza, G. Gasbarrini

Research output: Contribution to journalArticle

Abstract

Inflammatory reactions of the gut mucosa occur as a normal response to the enormous variety of antigens present in the bowel lumen. In most cases there is an effective downregulation of the immune reaction leading to tissue reparation and institution of oral tolerance. Inflammatory bowel diseases are characterized by a severe alteration of mucosal immunoregulation that involves all the components of the immune system. A critical role is played by T-lymphocytes which determine the cytokine pattern and regulate the activity of other immune system cells. Induction and maintenance of mucosal inflammation in these type of diseases is probably the result of an abnormal immunological response to common antigens (bacterial products, drugs, dietary antigens) in genetic susceptible hosts.

Original languageEnglish
Pages (from-to)26-29
Number of pages4
JournalGastroenterology International
Volume10
Issue numberSUPPL. 1
Publication statusPublished - 1997

Fingerprint

Immune System
Inflammation
Bacterial Antigens
Antigens
Inflammatory Bowel Diseases
Mucous Membrane
Down-Regulation
Maintenance
Cytokines
T-Lymphocytes
Pharmaceutical Preparations

Keywords

  • Cytokines
  • Inflammation
  • Inflammatory bowel disease
  • Pathogenesis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Manna, R., Latteri, M., De Santis, A., Romito, A., Gemelli, P., Corazza, G., & Gasbarrini, G. (1997). Inflammation of the bowel. Gastroenterology International, 10(SUPPL. 1), 26-29.

Inflammation of the bowel. / Manna, R.; Latteri, M.; De Santis, A.; Romito, A.; Gemelli, P.; Corazza, G.; Gasbarrini, G.

In: Gastroenterology International, Vol. 10, No. SUPPL. 1, 1997, p. 26-29.

Research output: Contribution to journalArticle

Manna, R, Latteri, M, De Santis, A, Romito, A, Gemelli, P, Corazza, G & Gasbarrini, G 1997, 'Inflammation of the bowel', Gastroenterology International, vol. 10, no. SUPPL. 1, pp. 26-29.
Manna R, Latteri M, De Santis A, Romito A, Gemelli P, Corazza G et al. Inflammation of the bowel. Gastroenterology International. 1997;10(SUPPL. 1):26-29.
Manna, R. ; Latteri, M. ; De Santis, A. ; Romito, A. ; Gemelli, P. ; Corazza, G. ; Gasbarrini, G. / Inflammation of the bowel. In: Gastroenterology International. 1997 ; Vol. 10, No. SUPPL. 1. pp. 26-29.
@article{992eb431640a46a1bef8e85fae08226b,
title = "Inflammation of the bowel",
abstract = "Inflammatory reactions of the gut mucosa occur as a normal response to the enormous variety of antigens present in the bowel lumen. In most cases there is an effective downregulation of the immune reaction leading to tissue reparation and institution of oral tolerance. Inflammatory bowel diseases are characterized by a severe alteration of mucosal immunoregulation that involves all the components of the immune system. A critical role is played by T-lymphocytes which determine the cytokine pattern and regulate the activity of other immune system cells. Induction and maintenance of mucosal inflammation in these type of diseases is probably the result of an abnormal immunological response to common antigens (bacterial products, drugs, dietary antigens) in genetic susceptible hosts.",
keywords = "Cytokines, Inflammation, Inflammatory bowel disease, Pathogenesis",
author = "R. Manna and M. Latteri and {De Santis}, A. and A. Romito and P. Gemelli and G. Corazza and G. Gasbarrini",
year = "1997",
language = "English",
volume = "10",
pages = "26--29",
journal = "Gastroenterology International",
issn = "0950-5911",
publisher = "International Universities Press Inc.",
number = "SUPPL. 1",

}

TY - JOUR

T1 - Inflammation of the bowel

AU - Manna, R.

AU - Latteri, M.

AU - De Santis, A.

AU - Romito, A.

AU - Gemelli, P.

AU - Corazza, G.

AU - Gasbarrini, G.

PY - 1997

Y1 - 1997

N2 - Inflammatory reactions of the gut mucosa occur as a normal response to the enormous variety of antigens present in the bowel lumen. In most cases there is an effective downregulation of the immune reaction leading to tissue reparation and institution of oral tolerance. Inflammatory bowel diseases are characterized by a severe alteration of mucosal immunoregulation that involves all the components of the immune system. A critical role is played by T-lymphocytes which determine the cytokine pattern and regulate the activity of other immune system cells. Induction and maintenance of mucosal inflammation in these type of diseases is probably the result of an abnormal immunological response to common antigens (bacterial products, drugs, dietary antigens) in genetic susceptible hosts.

AB - Inflammatory reactions of the gut mucosa occur as a normal response to the enormous variety of antigens present in the bowel lumen. In most cases there is an effective downregulation of the immune reaction leading to tissue reparation and institution of oral tolerance. Inflammatory bowel diseases are characterized by a severe alteration of mucosal immunoregulation that involves all the components of the immune system. A critical role is played by T-lymphocytes which determine the cytokine pattern and regulate the activity of other immune system cells. Induction and maintenance of mucosal inflammation in these type of diseases is probably the result of an abnormal immunological response to common antigens (bacterial products, drugs, dietary antigens) in genetic susceptible hosts.

KW - Cytokines

KW - Inflammation

KW - Inflammatory bowel disease

KW - Pathogenesis

UR - http://www.scopus.com/inward/record.url?scp=0030779590&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030779590&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0030779590

VL - 10

SP - 26

EP - 29

JO - Gastroenterology International

JF - Gastroenterology International

SN - 0950-5911

IS - SUPPL. 1

ER -