Inflammation, pressure ulcers and poor functional status predict negative rehabilitation outcomes in postacute geriatric patients

Roberto Aquilani, Ginetto Carlo Zuccarelli, Roberto Maestri, Carla Rutili, Mauro Colombo, Anna Maria Condino, Annalisa Barbieri, Alessandra Cecchetti, Simona Vanzati, Edi Bonazza, Franco Lafiandra, Daniela Buonocore, Manuela Verri, Maurizia Dossena, Federica Boschi

Research output: Contribution to journalArticlepeer-review

Abstract

The purposes of this retrospective study were to document the prevalence of serum C-reactive protein (CRP), a biomarker of inflammation, and its potential predictive value for Rehabilitation outcomes in post-acute elderly inpatients. The medical records of 304 elderly subjects admitted to our Rehabilitation Institute for any disease following an acute event were examined. High levels of CRP (> 0.5 mg/dl) were present in 100% of the subjects, and the value > 1.5 mg/dl (n = 86) predicted unfavourable outcomes (n = 28; 32.5% of the patients: death or transfer to other institutions). Among the patients with favourable outcomes (discharge home n = 255), 62.7% still exhibited severe disabilities. Pressure ulcers and low functional status also predicted unfavourable outcomes. The study highlights the need for future investigations into the possible reduction of CRP levels, after an intensive nutritional approach and combined physical interventions.

Original languageEnglish
Pages (from-to)463-467
Number of pages5
JournalAging Clin. Exp. Res.
Volume33
Issue number2
DOIs
Publication statusPublished - Feb 2021

Keywords

  • Aged
  • Functional Status
  • Humans
  • Inflammation
  • Pressure Ulcer/epidemiology
  • Retrospective Studies
  • Treatment Outcome

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