Inflammation profile of four early onset crohn patients

Annalisa Marcuzzi, Martina Girardelli, Anna Monica Bianco, Stefano Martelossi, Andrea Magnolato, Alberto Tommasini, Sergio Crovella

Research output: Contribution to journalArticlepeer-review

Abstract

Crohn disease (CD) is a multifactorial disorder affecting mainly young adults. Sometimes, however, it can present in the first year of life (Early onset Crohn disease (EOCD)) showing an unpredictable course and can often be more severe than at older ages. Some cases have been associated to an underlying primary immunodeficiency such as IL10R deficiency. We studied the functional response to IL-10 and the genotype of IL-10 receptor in four patients with early onset crohn-like colitis. We found an IL10R variant, which may be associated with a decreased response to the cytokine in one patient. Further studies to determine its pathogenic effect should be performed. In addition IL-10 mediated inhibition of LPS-induced TNFα expression was measured in patient's monocytes.

Original languageEnglish
Pages (from-to)282-285
Number of pages4
JournalGene
Volume493
Issue number2
DOIs
Publication statusPublished - Feb 10 2012

Keywords

  • Crohn disease
  • Cytokines
  • Inflammatory bowel disease
  • Polymorphism analysis

ASJC Scopus subject areas

  • Genetics

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