Inflammatory and innate immune cells in cancer microenvironment and progression

Patrick Brennecke, Paola Allavena, Maria Laface, Alberto Mantovani, Barbara Bottazzi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

It is established that persistent inflammation promotes tumor formation and disease progression. The inflammatory microenvironment within solid tumors is composed of soluble and cellular components, including several cytokines and chemokines, growth factors, enzymes, as well as host cells: endothelial cells, fibroblasts, and leukocytes. Tumor-associated myeloid cells (TAMC) represent the preponderant part of tumor-infiltrating leukocytes; they are a very heterogeneous entity of cells regulating diverse aspects of cancer biology. TAMC can directly support cancer growth and survival and regulate angiogenesis, metastasis, as well as immunosuppression. Accordingly, TAMC have recently become targets of new and innovative anticancer therapy approaches. This chapter will review the main characteristics of tumor-associated myeloid cells and their role in promoting tumor growth and dissemination. In addition, we will briefly address new therapeutic possibilities based on targeting of TAMC.

Original languageEnglish
Title of host publicationCancer Immunology: A Translational Medicine Context
PublisherSpringer Berlin Heidelberg
Pages9-28
Number of pages20
ISBN (Print)9783662440063, 9783662440056
DOIs
Publication statusPublished - Jan 1 2015

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

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