Abstract
In addition to aberrant transformed cells, tumors are tissues that contain host components, including stromal cells, vascular cells (ECs) and their precursors, and immune cells. All these constituents interact with each other at the cellular and molecular levels, resulting in the production of an intricate and heterogeneous complex of cells and matrix defined as the tumor microenvironment. Several pathways involved in these interactions have been investigated both in pathological and physiological scenarios, and diverse molecules are currently targets of chemotherapeutic and preventive drugs. Many phytochemicals and their derivatives show the ability to inhibit tumor progression, angiogenesis, and metastasis, exerting effects on the tumor microenvironment. In this review, we will outline the principal players and mechanisms involved in the tumor microenvironment network and we will discuss some interesting compounds aimed at interrupting these interactions and blocking tumor insurgence and progression. The considerations provided will be crucial for the design of new preventive approaches to the reduction in cancer risk that need to be applied to large populations composed of apparently healthy individuals.
| Original language | English |
|---|---|
| Pages (from-to) | 401-426 |
| Number of pages | 26 |
| Journal | Cancer Treatment and Research |
| Volume | 159 |
| DOIs | |
| Publication status | Published - 2014 |
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Keywords
- Angiogenesis
- Anti-angiogenic therapy
- Chemoprevention
- Inflammation
- Tumour microenvironment
ASJC Scopus subject areas
- Oncology
- Cancer Research
- Medicine(all)
Cite this
Inflammatory angiogenesis and the tumor microenvironment as targets for cancer therapy and prevention. / Bruno, Antonino; Pagani, Arianna; Magnani, Elena; Rossi, Teresa; Noonan, Douglas M.; Cantelmo, Anna Rita; Albini, Adriana.
In: Cancer Treatment and Research, Vol. 159, 2014, p. 401-426.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inflammatory angiogenesis and the tumor microenvironment as targets for cancer therapy and prevention
AU - Bruno, Antonino
AU - Pagani, Arianna
AU - Magnani, Elena
AU - Rossi, Teresa
AU - Noonan, Douglas M.
AU - Cantelmo, Anna Rita
AU - Albini, Adriana
PY - 2014
Y1 - 2014
N2 - In addition to aberrant transformed cells, tumors are tissues that contain host components, including stromal cells, vascular cells (ECs) and their precursors, and immune cells. All these constituents interact with each other at the cellular and molecular levels, resulting in the production of an intricate and heterogeneous complex of cells and matrix defined as the tumor microenvironment. Several pathways involved in these interactions have been investigated both in pathological and physiological scenarios, and diverse molecules are currently targets of chemotherapeutic and preventive drugs. Many phytochemicals and their derivatives show the ability to inhibit tumor progression, angiogenesis, and metastasis, exerting effects on the tumor microenvironment. In this review, we will outline the principal players and mechanisms involved in the tumor microenvironment network and we will discuss some interesting compounds aimed at interrupting these interactions and blocking tumor insurgence and progression. The considerations provided will be crucial for the design of new preventive approaches to the reduction in cancer risk that need to be applied to large populations composed of apparently healthy individuals.
AB - In addition to aberrant transformed cells, tumors are tissues that contain host components, including stromal cells, vascular cells (ECs) and their precursors, and immune cells. All these constituents interact with each other at the cellular and molecular levels, resulting in the production of an intricate and heterogeneous complex of cells and matrix defined as the tumor microenvironment. Several pathways involved in these interactions have been investigated both in pathological and physiological scenarios, and diverse molecules are currently targets of chemotherapeutic and preventive drugs. Many phytochemicals and their derivatives show the ability to inhibit tumor progression, angiogenesis, and metastasis, exerting effects on the tumor microenvironment. In this review, we will outline the principal players and mechanisms involved in the tumor microenvironment network and we will discuss some interesting compounds aimed at interrupting these interactions and blocking tumor insurgence and progression. The considerations provided will be crucial for the design of new preventive approaches to the reduction in cancer risk that need to be applied to large populations composed of apparently healthy individuals.
KW - Angiogenesis
KW - Anti-angiogenic therapy
KW - Chemoprevention
KW - Inflammation
KW - Tumour microenvironment
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UR - http://www.scopus.com/inward/citedby.url?scp=84897342939&partnerID=8YFLogxK
U2 - 10.1007/978-3-642-38007-5_23
DO - 10.1007/978-3-642-38007-5_23
M3 - Article
C2 - 24114493
AN - SCOPUS:84897342939
VL - 159
SP - 401
EP - 426
JO - Cancer Treatment and Research
JF - Cancer Treatment and Research
SN - 0927-3042
ER -