TY - JOUR
T1 - Inflammatory bowel disease course in liver transplant versus non-liver transplant patients for primary sclerosing cholangitis
T2 - LIVIBD, an IG-IBD study
AU - Italian Group for the study of Inflammatory Bowel Disease IG-IBD
AU - Ribaldone, Davide Giuseppe
AU - Imperatore, Nicola
AU - Le Grazie, Marco
AU - Furfaro, Federica
AU - Balestrieri, Paola
AU - De Blasio, Federico
AU - Fagoonee, Sharmila
AU - Mosso, Elena
AU - Boano, Valentina
AU - Reggio, Dario
AU - Sarli, Ennio
AU - Castiglione, Fabiana
AU - Milla, Monica
AU - Vecchi, Maurizio
AU - Saracco, Giorgio Maria
AU - Salizzoni, Mauro
AU - Romagnoli, Renato
AU - Fiorino, Gionata
AU - Astegiano, Marco
PY - 2020
Y1 - 2020
N2 - Background: Data regarding the effect of orthotopic liver transplantation (OLT) for primary sclerosing cholangitis (PSC) on inflammatory bowel disease (IBD) course are scarce and conflicting. Aims: To compare the incidence of refractory IBD in two groups (OLT and non-OLT) of patients affected by IBD and PSC. Methods: An observational, multicentre, cohort retrospective study was conducted by the Italian Group for the study of IBD in Italy. The primary outcome was the need for biologic therapy or bowel resection for medically refractory IBD or hospitalization due to IBD relapse during the follow-up. Secondary outcomes were rate of colonic dysplasia, colorectal cancer, other solid tumours, lymphoma. Results: Eighty-four patients were included in the study. The primary outcome was not different between OLT and non-OLT groups (11/27, 40.7%, versus 20/57, 35.1%, respectively, p = 0.62). The lymphoma and other tumours (thyroid cancer, kidney cancer, ileal tumour, ovarian cancer, cervical cancer) rates were significantly higher in the OLT group (p = 0.04 and p = 0.005, respectively), at the limit of statistical significance for high-grade colonic dysplasia (p = 0.06). Conclusion: OLT in patients affected by IBD and PSC is not a risk factor for a more severe IBD course, but it is associated with a higher occurrence of cancer.
AB - Background: Data regarding the effect of orthotopic liver transplantation (OLT) for primary sclerosing cholangitis (PSC) on inflammatory bowel disease (IBD) course are scarce and conflicting. Aims: To compare the incidence of refractory IBD in two groups (OLT and non-OLT) of patients affected by IBD and PSC. Methods: An observational, multicentre, cohort retrospective study was conducted by the Italian Group for the study of IBD in Italy. The primary outcome was the need for biologic therapy or bowel resection for medically refractory IBD or hospitalization due to IBD relapse during the follow-up. Secondary outcomes were rate of colonic dysplasia, colorectal cancer, other solid tumours, lymphoma. Results: Eighty-four patients were included in the study. The primary outcome was not different between OLT and non-OLT groups (11/27, 40.7%, versus 20/57, 35.1%, respectively, p = 0.62). The lymphoma and other tumours (thyroid cancer, kidney cancer, ileal tumour, ovarian cancer, cervical cancer) rates were significantly higher in the OLT group (p = 0.04 and p = 0.005, respectively), at the limit of statistical significance for high-grade colonic dysplasia (p = 0.06). Conclusion: OLT in patients affected by IBD and PSC is not a risk factor for a more severe IBD course, but it is associated with a higher occurrence of cancer.
KW - OLT
KW - Orthotopic liver transplantation
KW - Primary sclerosing cholangitis
KW - PSC
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U2 - 10.1016/j.dld.2020.09.011
DO - 10.1016/j.dld.2020.09.011
M3 - Article
AN - SCOPUS:85091202094
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
SN - 1590-8658
ER -