Inflammatory Bowel Disease Meets Systems Biology: A Multi-Omics Challenge and Frontier

Orazio Palmieri, Tommaso Mazza, Stefano Castellana, Anna Panza, Tiziana Latiano, Giuseppe Corritore, Angelo Andriulli, Anna Latiano

Research output: Contribution to journalReview articlepeer-review


The inflammatory bowel disease (IBD) is a systemic disease that is characterized by the inflammation of the gastrointestinal tract. It includes ulcerative colitis and the Crohn's disease. Presently, IBD is one of the most investigated common complex human disorders, although its causes remain unclear. Multi-omics mechanisms involving genomic, transcriptomic, proteomic, and epigenomic variations, not to forget the miRNome, together with environmental contributions, result in an impairment of the immune system in persons with IBD. Such interactions at multiple levels of biology and in concert with the environment constitute the actual engine of this complex disease, demanding a multifactorial and multi-omics perspective to better understand the root causes of IBD. This expert analysis reviews and examines the latest literature and underscores, from the perspective of systems biology, the value of multi-omics technologies as opportunities to unravel the "IBD integrome." We anticipate that multi-omics research will accelerate the new discoveries and insights on IBD in the near future. It shall also pave the way for early diagnosis and help clinicians and families with IBD to forecast and make informed decisions about the prognosis and, possibly, personalized therapeutics in the future.

Original languageEnglish
Pages (from-to)692-698
Number of pages7
JournalOMICS A Journal of Integrative Biology
Issue number12
Publication statusPublished - Dec 1 2016


  • Genomics
  • IBD
  • Metabolomics
  • Metagenomics
  • Metylomics
  • Proteomics

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Genetics


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