Inflammatory bowel diseases, celiac disease, and bone

Research output: Contribution to journalArticle

Abstract

The article summarizes the current knowledge on the pathogenesis, clinical aspects and treatment of bone problems in the major inflammatory bowel diseases (Crohn's disease and ulcerative colitis) and celiac disease. It presents the physiological relationship between intestine and bone as well as the alterations determined by disease-disrupted intestinal integrity. Two hypotheses about the pathogenetic mechanisms of bone metabolism derangements and bone loss are discussed: the classical one, that indicates calcium malabsorption as the main culprit, and the new one, that emphasizes the role of inflammation. The article summarizes the available epidemiological data about osteopenia/osteoporosis and fragility fractures in these chronic intestinal diseases and presents the state-of-the-art treatment options.

Original languageEnglish
Pages (from-to)54-65
Number of pages12
JournalArchives of Biochemistry and Biophysics
Volume503
Issue number1
DOIs
Publication statusPublished - Nov 2010

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Keywords

  • Bone density
  • Calcium
  • Celiac disease
  • Crohn's disease
  • Fractures
  • Inflammatory bowel diseases
  • Osteoporosis
  • Ulcerative colitis
  • Vitamin D

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology
  • Medicine(all)

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